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anti-Bestrophin 1 (BEST1) Antibodies

BEST1 encodes a member of the bestrophin gene family. Additionally we are shipping Bestrophin 1 Proteins (9) and Bestrophin 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BEST1 7439 O76090
BEST1 24115 O88870
BEST1 293735  
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Top anti-Bestrophin 1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IP, WB   0.25 mg Log in to see 10 to 12 Days
$485.10
Details
Human Mouse Un-conjugated WB Western Blot analysis of BEST1 expression in transfected 293T cell lin... 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: SK-N-... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using BEST1 a... 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of Mouse eyes tissue, using BEST1 Polyclonal Ant... 200 μL Log in to see 8 to 9 Days
$588.50
Details

BEST1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , ,
,
Mouse (Murine) , ,

Rat (Rattus) , ,

Top referenced anti-Bestrophin 1 Antibodies

  1. Human Polyclonal Bestrophin 1 Primary Antibody for EIA, WB - ABIN492809 : Marmorstein, McLaughlin, Stanton, Yan, Crabb, Marmorstein: Bestrophin interacts physically and functionally with protein phosphatase 2A. in The Journal of biological chemistry 2002 (PubMed)

  2. Human Polyclonal Bestrophin 1 Primary Antibody for WB - ABIN521346 : Kuo, Abdullaev, Hyzinski-García, Mongin: Effects of alternative splicing on the function of bestrophin-1 calcium-activated chloride channels. in The Biochemical journal 2014 (PubMed)

More Antibodies against Bestrophin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin 1 (dBest1) as the Drosophila Cl(swell) channel

  2. bestrophin-1 chloride current is dually regulated by calcium and cell volume

Human Bestrophin 1 (BEST1) interaction partners

  1. HEK293T cells transfected with the identified BEST1 mutant showed significantly small currents compared to those transfected with the wild-type gene, whereas cells cotransfected with mutant and wild-type BEST1 showed good chloride conductance

  2. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.

  3. We describe a novel mutation within the BEST1 gene of the heterozygous form giving rise to vitelliform lesions and secondary neovascularization successfully treated in a child with a course of bevacizumab.

  4. Dysfunction of bestrophin 1 may result in abnormal ion and fluid transport by the retinal pigment epithelium (RPE (show RPE Antibodies)) disturbing and even disrupting direct interactions between the RPE (show RPE Antibodies) and the photoreceptors.

  5. Two novel BEST1 mutations and associated clinical observations have been found in two unrelated patients with Best vitelliform macular dystrophy.

  6. Genetic sequence analysis of BEST1 is important in the diagnosis of Best vitelliform dystrophy, particularly in unusual cases, and helps to further our knowledge and understanding of this disease.

  7. Best1 I366fsX18 differs from Best1 in that it lacks most of the cytosolic C-terminal domain, suggesting that the loss of this region contributes significantly to the pathogenesis of ARB in this patient.

  8. Three novel BEST1 mutations are described, suggesting that many deleterious variants in BEST1 resulting in haploinsufficiency are still unknown.

  9. BEST1 influences transepithelial electrical properties and Ca2 (show CA2 Antibodies)+ signaling in human retinal pigment epithelium.

  10. The features and combinations of different BEST1 mutations as well as epistatic effects may influence phenotype expression in Chinese patients with bestrophinopathy.

Mouse (Murine) Bestrophin 1 (BEST1) interaction partners

  1. Data suggest that the ion channels CaV1.3 (show CACNA1D Antibodies), bestrophin-1 and maxiK (show KCNMA1 Antibodies) were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (show RPE Antibodies)).

  2. Best1-mediated astrocytic glutamate (show GRIN1 Antibodies) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 Antibodies) (NMDAR (show GRIN1 Antibodies)) and modulates NMDAR (show GRIN1 Antibodies)-dependent synaptic plasticity.

  3. Bestrophin-1 functions as an intracellular Cl channel which helps to accumulate and to release Ca(2 (show CA2 Antibodies)+) from stores by conducting the counterion for Ca(2 (show CA2 Antibodies)+).

  4. Best1, located at the microdomains near the synaptic junctions, has a significantly high permeability to glutamate (show GRIN1 Antibodies) in vivo.

  5. Results show that different mutations in Best1 cause differential effects on its localization and that this effect varies with the presence or absence of wild-type (WT) Best1.

  6. Astrocytic glutamate (show GRIN1 Antibodies) via Best1 channel targets and activates synaptic NMDA receptors.

  7. Upon activation of protease activated receptor 1 (PAR1 (show F2R Antibodies)), an increase in intracellular Ca2 (show CA2 Antibodies)+ concentration leads to an opening of Best1 channels and subsequent release of glutamate (show GRIN1 Antibodies) in cultured astrocytes.

  8. Ultrastructural analyses demonstrate that TREK-1 (show KCNK2 Antibodies) is preferentially localized at cell body and processes, whereas Best1 is mostly found in microdomains of astrocytes near synapses.

  9. study reports that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 anion channel

  10. SOX9 (show SOX9 Antibodies), through interaction with microphthalmia-associated transcription factor (MITF (show MITF Antibodies)) and OTX2 (show OTX2 Antibodies), regulates BEST1 expression in the retinal pigment epithelium.

Pig (Porcine) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin-1 knock-down increases phagocytosis in primary porcine RPE (show RPE Antibodies) cells.

  2. Retinal pigment epithelium bestrophin-1 possibly conducts Cl(-) as counter ion for Ca(2 (show CA2 Antibodies)+) uptake into cytosolic Ca(2 (show CA2 Antibodies)+) stores.

  3. examined the quaternary structure of native best-1 and found that it migrates as a single species with a Stokes radius of 7.3 nm, sedimentation coefficient (S20 (show RPS20 Antibodies),w) of 4.9, and partial specific volume (nu) of 0.80 ml/g

Bestrophin 1 (BEST1) Antigen Profile

Protein Summary

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Gene names and symbols associated with anti-Bestrophin 1 (BEST1) Antibodies

  • Bestrophin 1 (Best1) antibody
  • bestrophin 1 (BEST1) antibody
  • bestrophin 1 (best1) antibody
  • Bestrophin 1 (Bm1_25500) antibody
  • bestrophin 1 (Best1) antibody
  • anon-WO0118547.380 antibody
  • ARB antibody
  • BEST antibody
  • best-1 antibody
  • BEST1 antibody
  • Bmd antibody
  • CG6264 antibody
  • Dbest antibody
  • dbest1 antibody
  • dmBest1 antibody
  • Dmel\\CG6264 antibody
  • mBest1 antibody
  • RP50 antibody
  • TU15B antibody
  • Vmd2 antibody

Protein level used designations for anti-Bestrophin 1 (BEST1) Antibodies

Best1-PA , Best1-PB , Best1-PC , Best1-PD , CG6264-PA , CG6264-PB , CG6264-PC , CG6264-PD , bestrophin 1 , bestrophin-1 , Bestrophin 1 , bestrophin-1-like , Best disease , Best1V1Delta2 , vitelliform macular dystrophy protein 2 , best macular dystrophy , vitelliform macular dystrophy 2 homolog , vitelliform macular dystrophy protein 2 homolog , vitelliform macular dystrophy (Best disease, bestrophin) , Bestrophin-1

GENE ID SPECIES
53431 Drosophila melanogaster
466630 Pan troglodytes
100302038 Xenopus (Silurana) tropicalis
423124 Gallus gallus
483791 Canis lupus familiaris
508924 Bos taurus
6100000 Brugia malayi
100434568 Pongo abelii
7439 Homo sapiens
24115 Mus musculus
293735 Rattus norvegicus
397169 Sus scrofa
Selected quality suppliers for anti-Bestrophin 1 (BEST1) Antibodies
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