You are viewing an incomplete version of our website. Please click to reload the website as full version.

Bestrophin 1 (BEST1) ELISA Kits

BEST1 encodes a member of the bestrophin gene family. Additionally we are shipping Bestrophin 1 Antibodies (29) and Bestrophin 1 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
BEST1 7439 O76090
BEST1 24115 O88870
BEST1 293735  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Bestrophin 1 ELISA Kits at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Chicken
48 Tests Log in to see 16 to 21 Days
$716.57
Details
Human
48 Tests Log in to see 16 to 21 Days
$716.57
Details
Mouse
48 Tests Log in to see 16 to 21 Days
$716.57
Details
Rat
48 Tests Log in to see 16 to 21 Days
$716.57
Details

More ELISA Kits for Bestrophin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin 1 (dBest1) as the Drosophila Cl(swell) channel

  2. bestrophin-1 chloride current is dually regulated by calcium and cell volume

Human Bestrophin 1 (BEST1) interaction partners

  1. HEK293T cells transfected with the identified BEST1 mutant showed significantly small currents compared to those transfected with the wild-type gene, whereas cells cotransfected with mutant and wild-type BEST1 showed good chloride conductance

  2. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.

  3. We describe a novel mutation within the BEST1 gene of the heterozygous form giving rise to vitelliform lesions and secondary neovascularization successfully treated in a child with a course of bevacizumab.

  4. Dysfunction of bestrophin 1 may result in abnormal ion and fluid transport by the retinal pigment epithelium (RPE) disturbing and even disrupting direct interactions between the RPE and the photoreceptors.

  5. Two novel BEST1 mutations and associated clinical observations have been found in two unrelated patients with Best vitelliform macular dystrophy.

  6. Genetic sequence analysis of BEST1 is important in the diagnosis of Best vitelliform dystrophy, particularly in unusual cases, and helps to further our knowledge and understanding of this disease.

  7. Best1 I366fsX18 differs from Best1 in that it lacks most of the cytosolic C-terminal domain, suggesting that the loss of this region contributes significantly to the pathogenesis of ARB in this patient.

  8. Three novel BEST1 mutations are described, suggesting that many deleterious variants in BEST1 resulting in haploinsufficiency are still unknown.

  9. BEST1 influences transepithelial electrical properties and Ca2 (show CA2 ELISA Kits)+ signaling in human retinal pigment epithelium.

  10. The features and combinations of different BEST1 mutations as well as epistatic effects may influence phenotype expression in Chinese patients with bestrophinopathy.

Mouse (Murine) Bestrophin 1 (BEST1) interaction partners

  1. Data suggest that the ion channels CaV1.3, bestrophin-1 and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE).

  2. Best1-mediated astrocytic glutamate (show GRIN1 ELISA Kits) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 ELISA Kits) (NMDAR (show GRIN1 ELISA Kits)) and modulates NMDAR (show GRIN1 ELISA Kits)-dependent synaptic plasticity.

  3. Bestrophin-1 functions as an intracellular Cl channel which helps to accumulate and to release Ca(2 (show CA2 ELISA Kits)+) from stores by conducting the counterion for Ca(2 (show CA2 ELISA Kits)+).

  4. Best1, located at the microdomains near the synaptic junctions, has a significantly high permeability to glutamate (show GRIN1 ELISA Kits) in vivo.

  5. Results show that different mutations in Best1 cause differential effects on its localization and that this effect varies with the presence or absence of wild-type (WT) Best1.

  6. Astrocytic glutamate (show GRIN1 ELISA Kits) via Best1 channel targets and activates synaptic NMDA receptors.

  7. Upon activation of protease activated receptor 1 (PAR1 (show F2R ELISA Kits)), an increase in intracellular Ca2 (show CA2 ELISA Kits)+ concentration leads to an opening of Best1 channels and subsequent release of glutamate (show GRIN1 ELISA Kits) in cultured astrocytes.

  8. Ultrastructural analyses demonstrate that TREK-1 (show KCNK2 ELISA Kits) is preferentially localized at cell body and processes, whereas Best1 is mostly found in microdomains of astrocytes near synapses.

  9. study reports that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 anion channel

  10. SOX9 (show SOX9 ELISA Kits), through interaction with microphthalmia-associated transcription factor (MITF (show MITF ELISA Kits)) and OTX2 (show OTX2 ELISA Kits), regulates BEST1 expression in the retinal pigment epithelium.

Pig (Porcine) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin-1 knock-down increases phagocytosis in primary porcine RPE cells.

  2. Retinal pigment epithelium bestrophin-1 possibly conducts Cl(-) as counter ion for Ca(2 (show CA2 ELISA Kits)+) uptake into cytosolic Ca(2 (show CA2 ELISA Kits)+) stores.

  3. examined the quaternary structure of native best-1 and found that it migrates as a single species with a Stokes radius of 7.3 nm, sedimentation coefficient (S20 (show RPS20 ELISA Kits),w) of 4.9, and partial specific volume (nu) of 0.80 ml/g

Bestrophin 1 (BEST1) Antigen Profile

Antigen Summary

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Gene names and symbols associated with Bestrophin 1 (BEST1) ELISA Kits

  • Bestrophin 1 (Best1) antibody
  • bestrophin 1 (BEST1) antibody
  • bestrophin 1 (best1) antibody
  • Bestrophin 1 (Bm1_25500) antibody
  • bestrophin 1 (Best1) antibody
  • anon-WO0118547.380 antibody
  • ARB antibody
  • BEST antibody
  • best-1 antibody
  • BEST1 antibody
  • Bmd antibody
  • CG6264 antibody
  • Dbest antibody
  • dbest1 antibody
  • dmBest1 antibody
  • Dmel\\CG6264 antibody
  • mBest1 antibody
  • RP50 antibody
  • TU15B antibody
  • Vmd2 antibody

Protein level used designations for Bestrophin 1 (BEST1) ELISA Kits

Best1-PA , Best1-PB , Best1-PC , Best1-PD , CG6264-PA , CG6264-PB , CG6264-PC , CG6264-PD , bestrophin 1 , bestrophin-1 , Bestrophin 1 , bestrophin-1-like , Best disease , Best1V1Delta2 , vitelliform macular dystrophy protein 2 , best macular dystrophy , vitelliform macular dystrophy 2 homolog , vitelliform macular dystrophy protein 2 homolog , vitelliform macular dystrophy (Best disease, bestrophin) , Bestrophin-1

GENE ID SPECIES
53431 Drosophila melanogaster
466630 Pan troglodytes
100302038 Xenopus (Silurana) tropicalis
423124 Gallus gallus
483791 Canis lupus familiaris
508924 Bos taurus
6100000 Brugia malayi
100434568 Pongo abelii
7439 Homo sapiens
24115 Mus musculus
293735 Rattus norvegicus
397169 Sus scrofa
Selected quality suppliers for Bestrophin 1 (BEST1) ELISA Kits
Did you look for something else?