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Bestrophin 1 (BEST1) ELISA Kits

BEST1 encodes a member of the bestrophin gene family. Additionally we are shipping Bestrophin 1 Antibodies (29) and Bestrophin 1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human BEST1 BEST1 7439 O76090
Anti-Mouse BEST1 BEST1 24115 O88870
Anti-Rat BEST1 BEST1 293735  
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More ELISA Kits for Bestrophin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin 1 (dBest1) as the Drosophila Cl(swell) channel

  2. bestrophin-1 chloride current is dually regulated by calcium and cell volume

Human Bestrophin 1 (BEST1) interaction partners

  1. A clinical picture similar to autosomal recessive bestrophinopathy can also be caused by a single heterozygous mutation in the BEST1 gene, such as the c.614T>C (p.I205T) variant in this family.

  2. The secondary structure of Best1 and the effect of calcium have been described.

  3. BVMD could present with other ocular disorders such as ACG and FCE (show FECH ELISA Kits). We also found 2 novel disease-causing mutations (p.Thr307Asp, p.Arg47His) of the BEST1 gene, one of which (p.Arg47His) has also been reported in adult-onset vitelliform macular dystrophy (AVMD (show PRPH2 ELISA Kits))

  4. Two previously unreported disease-associated variants in the BEST1 gene (p.Gly15Arg and p.Arg105Gly) were found in Slovenian patients with Best disease.

  5. Nuclear spheres modulate the expression of BEST1 and GADD45G (show GADD45G ELISA Kits)

  6. Progressive posterior chorioretinal changes occurred over time in the initial ADVIRC proband, leading to visual loss. The causative mutation in this patient falls in the transmembrane domain of the BEST1 protein, with unclear functional consequences.

  7. HEK293T cells transfected with the identified BEST1 mutant showed significantly small currents compared to those transfected with the wild-type gene, whereas cells cotransfected with mutant and wild-type BEST1 showed good chloride conductance

  8. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.

  9. We describe a novel mutation within the BEST1 gene of the heterozygous form giving rise to vitelliform lesions and secondary neovascularization successfully treated in a child with a course of bevacizumab.

  10. Dysfunction of bestrophin 1 may result in abnormal ion and fluid transport by the retinal pigment epithelium (RPE) disturbing and even disrupting direct interactions between the RPE and the photoreceptors.

Mouse (Murine) Bestrophin 1 (BEST1) interaction partners

  1. Data suggest that the ion channels CaV1.3, bestrophin-1 and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE).

  2. Best1-mediated astrocytic glutamate (show GRIN1 ELISA Kits) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 ELISA Kits) (NMDAR (show GRIN1 ELISA Kits)) and modulates NMDAR (show GRIN1 ELISA Kits)-dependent synaptic plasticity.

  3. Bestrophin-1 functions as an intracellular Cl channel which helps to accumulate and to release Ca(2 (show CA2 ELISA Kits)+) from stores by conducting the counterion for Ca(2 (show CA2 ELISA Kits)+).

  4. Best1, located at the microdomains near the synaptic junctions, has a significantly high permeability to glutamate (show GRIN1 ELISA Kits) in vivo.

  5. Results show that different mutations in Best1 cause differential effects on its localization and that this effect varies with the presence or absence of wild-type (WT) Best1.

  6. Astrocytic glutamate (show GRIN1 ELISA Kits) via Best1 channel targets and activates synaptic NMDA receptors.

  7. Upon activation of protease activated receptor 1 (PAR1 (show F2R ELISA Kits)), an increase in intracellular Ca2 (show CA2 ELISA Kits)+ concentration leads to an opening of Best1 channels and subsequent release of glutamate (show GRIN1 ELISA Kits) in cultured astrocytes.

  8. Ultrastructural analyses demonstrate that TREK-1 (show KCNK2 ELISA Kits) is preferentially localized at cell body and processes, whereas Best1 is mostly found in microdomains of astrocytes near synapses.

  9. study reports that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 anion channel

  10. SOX9 (show SOX9 ELISA Kits), through interaction with microphthalmia-associated transcription factor (MITF (show MITF ELISA Kits)) and OTX2 (show OTX2 ELISA Kits), regulates BEST1 expression in the retinal pigment epithelium.

Pig (Porcine) Bestrophin 1 (BEST1) interaction partners

  1. Bestrophin-1 knock-down increases phagocytosis in primary porcine RPE cells.

  2. Retinal pigment epithelium bestrophin-1 possibly conducts Cl(-) as counter ion for Ca(2 (show CA2 ELISA Kits)+) uptake into cytosolic Ca(2 (show CA2 ELISA Kits)+) stores.

  3. examined the quaternary structure of native best-1 and found that it migrates as a single species with a Stokes radius of 7.3 nm, sedimentation coefficient (S20 (show RPS20 ELISA Kits),w) of 4.9, and partial specific volume (nu) of 0.80 ml/g

Bestrophin 1 (BEST1) Antigen Profile

Antigen Summary

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Gene names and symbols associated with Bestrophin 1 (BEST1) ELISA Kits

  • Bestrophin 1 (Best1) antibody
  • bestrophin 1 (BEST1) antibody
  • bestrophin 1 (best1) antibody
  • Bestrophin 1 (Bm1_25500) antibody
  • bestrophin 1 (Best1) antibody
  • anon-WO0118547.380 antibody
  • ARB antibody
  • BEST antibody
  • best-1 antibody
  • BEST1 antibody
  • Bmd antibody
  • CG6264 antibody
  • Dbest antibody
  • dbest1 antibody
  • dmBest1 antibody
  • Dmel\\CG6264 antibody
  • mBest1 antibody
  • RP50 antibody
  • TU15B antibody
  • Vmd2 antibody

Protein level used designations for Bestrophin 1 (BEST1) ELISA Kits

Best1-PA , Best1-PB , Best1-PC , Best1-PD , CG6264-PA , CG6264-PB , CG6264-PC , CG6264-PD , bestrophin 1 , bestrophin-1 , Bestrophin 1 , bestrophin-1-like , Best disease , Best1V1Delta2 , vitelliform macular dystrophy protein 2 , best macular dystrophy , vitelliform macular dystrophy 2 homolog , vitelliform macular dystrophy protein 2 homolog , vitelliform macular dystrophy (Best disease, bestrophin) , Bestrophin-1

53431 Drosophila melanogaster
466630 Pan troglodytes
100302038 Xenopus (Silurana) tropicalis
423124 Gallus gallus
483791 Canis lupus familiaris
508924 Bos taurus
6100000 Brugia malayi
100434568 Pongo abelii
7439 Homo sapiens
24115 Mus musculus
293735 Rattus norvegicus
397169 Sus scrofa
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