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BEST2 is a member of the bestrophin gene family of anion channels. Additionally we are shipping Bestrophin 2 Antibodies (50) and many more products for this protein.
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BEST2 and BEST4 (show BEST4 Proteins) could be added to the lineage-specific genes of humans intestinal epithelial cells
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans.
identified three novel VMD2 (show BEST1 Proteins)-related human genes demonstrating a high degree of conservation in their respective RFP (show FPR2 Proteins)-TM domains [VMD2L1, VMD2L2 (show BEST4 Proteins), VMD2L3 (show BEST3 Proteins)]
we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW]
Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma.
Determined HCO3(-)/Cl(-) transport via Best2 and the effect of disease causing mutations.
suggest a role of bestrophin 1 (show BEST1 Proteins) and 2 for Ca(2 (show CA2 Proteins)+) dependent Cl(-) secretion in mouse airways
Asp (show C3 Proteins)-rich domain has two defined binding sites and D301A and D304A mutations may impact the binding of the metal ions
Results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia.
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon.
, vitelliform macular dystrophy 2-like 1
, VMD2-like gene 1
, vitelliform macular dystrophy 2-like protein 1