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BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Additionally we are shipping Bestrophin 3 Proteins (7) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal Bestrophin 3 Primary Antibody for EIA, IP - ABIN492815
Tsunenari, Sun, Williams, Cahill, Smallwood, Yau, Nathans: Structure-function analysis of the bestrophin family of anion channels. in The Journal of biological chemistry 2003
Cow (Bovine) Polyclonal Bestrophin 3 Primary Antibody for WB - ABIN2784052
Qu, Yu, Cui, Ying, Hartzell: Activation of bestrophin Cl- channels is regulated by C-terminal domains. in The Journal of biological chemistry 2007
results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB (show NFKB1 Antibodies) signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.
identified three novel VMD2 (show BEST1 Antibodies)-related human genes demonstrating a high degree of conservation in their respective RFP (show FPR2 Antibodies)-TM domains [VMD2L1 (show BEST2 Antibodies), VMD2L2 (show BEST4 Antibodies), VMD2L3]
These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study.
Our experiments present clear evidence of Best3 mRNA and protein expression in mouse kidney glomeruli
The channel activity of the mBest4 protein lacking the C-terminus (residues 353-669) was specifically inhibited by co-expression of C-terminal fragments of mBest4 having the inhibitory motif.
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD\; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002
, vitelliform macular dystrophy 2-like 3
, vitelliform macular dystrophy 2-like protein 3