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BHMT encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Additionally we are shipping BHMT Antibodies (91) and BHMT Kits (1) and many more products for this protein.
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The faster evolutionary rate of BHMT2 (show BHMT2 Proteins) overall suggests that selective constraints were reduced relative to BHMT.
Multiple SNPs in BHMT and BHMT2 (show BHMT2 Proteins) were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements.
Data suggest BHMT is activated by binding of potassium ions; role of potassium ions in BHMT appears to be structural; potassium ions facilitate specific binding of substrate homocysteine (rather than substrate betaine) to active site of the enzyme.
Study suggests BHMT holds considerable potential as a blood biomarker for acute liver injury.
Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy.
Known common single-nucleotide polymorphisms in MTRR (show MTRR Proteins) and BHMT genes may not be significant risk factors for cororonary artery disease.
Our study suggests that the polymorphism BHMT G742A may modulate the Down syndrome risk in Brazilian mothers.
The BHMT 742GA or AA genotypes associated with tobacco consumption (P = 0.016) increase the risk for head and neck squamous cell carcinoma.
A transcription variant of exon 4 of betaine-homocysteine methyltransferase (BHMT) produces a loss of function of BHMT in human hepatocarcinoma
Three SNPs (rs41272270, rs16876512, and rs6875201), located 28kb upstream, in the 5'-UTR and in intron 1 of BHMT, respectively, were significantly correlated with both BHMT activity and protein levels.
It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase (show MTR Proteins) pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked.
mouse blastocysts are unusual in being able to generate AdoMet (show MAT1A Proteins) not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT
a role for BHMT in energy homeostasis.
BHMT has an important role in Hcy, choline, and one-carbon homeostasis
The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death.
function for Bhmt involving modulation of Shh (show SHH Proteins) signaling to control beta-cell development.
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
betaine--homocysteine S-methyltransferase 1
, betaine-homocysteine methyltransferase