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BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. Additionally we are shipping BLOC1S1 Antibodies (18) and BLOC1S1 Kits (13) and many more products for this protein.
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The mitochondrial acetylation status controlled by Sirt3 (show SIRT3 Proteins) and its proposed opponent GCN5L1 is an important regulator of the metabolic adaptation of mitochondrial translation.
Using cancer cell lines, the study shows that BLOC1S1 mRNA is specifically cleaved by IRE1 (show ERN1 Proteins) at guanine 444, but only under conditions of IRE1 (show ERN1 Proteins) hyperactivation.
The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton.
BLOS1 interacts with KXD1.
GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria.
Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility.
Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis.
Experimental investigation of five specific genes, AP3B1 (show AP3B1 Proteins), ATP6AP1 (show ATP6AP1 Proteins), BLOC1S1, LAMP2 (show LAMP2 Proteins), and RAB11A (show RAB11A Proteins), has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.
Biogenesis of Lysosome-related Organelles co (show SNAPIN Proteins)mplex-1 (BLOC-1) subunit 1 (BLOS1).
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
TDH, responsible for mitochondrial production of acetyl-CoA (show LPCAT1 Proteins) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15 (show FBXO15 Proteins), an F-box protein (show FBXO30 Proteins) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
BLOS1 interacts with sorting nexin 2 (show SNX2 Proteins) and the ESCRT-I (show VPS28 Proteins) component TSG101 (show TSG101 Proteins) to mediate the sorting of EGFR (show EGFR Proteins) into endosomal compartments
Here we show that genetic deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB (show TFEB Proteins)), which acts as a master regulator of autophagy.
Mutations in the human genes encoding Snapin (show SNAPIN Proteins) and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models
Defects in all the 5 known components of BLOC-1 (show PLDN Proteins), including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 (show PLDN Proteins) plays a key role in organelle biogenesis.
These results indicate that the BLOC-1 (show PLDN Proteins) and AP-3 (show AP3B1 Proteins) protein complexes affect the targeting of SNARE (show VTI1B Proteins) and non-SNARE (show VTI1B Proteins) AP-3 (show AP3B1 Proteins) cargoes and suggest a function of the BLOC-1 (show PLDN Proteins) complex in membrane protein sorting.
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004
BLOC subunit 1
, BLOC-1 subunit 1
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1
, GCN5 general control of amino-acid synthesis 5-like 1
, GCN5-like protein 1
, MTA1-interacting coactivator
, biogenesis of lysosome-related organelles complex 1 subunit 1
, biogenesis of lysosome-related organelles complex-1, subunit 1
, GCN5 general control of amino acid synthesis-like 1
, general control of amino acid synthesis, yeast homolog-like 1
, general control of amino acid synthesis-like 1