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Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).. Additionally we are shipping BOD1 Kits (3) and BOD1 Proteins (3) and many more products for this protein.
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Human Polyclonal BOD1 Primary Antibody for FACS, IHC (p) - ABIN952229
Porter, McClelland, Khoudoli, Hunter, Andersen, McAinsh, Blow, Swedlow: Bod1, a novel kinetochore protein required for chromosome biorientation. in The Journal of cell biology 2007
Show all 2 references for ABIN952229
we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase.
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).
biorientation defective 1
, biorientation of chromosomes in cell division protein 1
, family with sequence similarity 44, member B
, biorientation defective protein 1
, bone length and organs 1