You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Biotin-Protein Ligase (HLCS) Antibodies

HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. Additionally we are shipping Biotin-Protein Ligase Proteins (5) and Biotin-Protein Ligase Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HLCS 110948 Q920N2
HLCS 3141 P50747
HLCS 288240  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Biotin-Protein Ligase Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC209197 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-HLCS antibody (ABIN2455633), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HLCS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-HLCS. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$529.83
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of HLCS transfected lysate using anti-HLCS MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with HLCS MaxPab rabbit polyclonal antibody (D01) . Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane 1: HLCS transfected lysate(80.80 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane 1: HLCS transfected lysate(80.80 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated WB Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane1:HLCS transfected lysate(79.86 KDa).Lane2:Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IHC, WB   100 μL Log in to see 3 to 4 Days
$607.50
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB   0.1 mL Log in to see 6 to 9 Days
$427.88
Details

HLCS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) ,


Human ,
,
,
Rat (Rattus) ,


More Antibodies against Biotin-Protein Ligase Interaction Partners

Human Biotin-Protein Ligase (HLCS) interaction partners

  1. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1 (show HDAC1 Antibodies), HDAC2 (show HDAC2 Antibodies) and HDAC7 (show HDAC7 Antibodies)

  2. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1 (show NCOR1 Antibodies)) and HDAC1 (histone deacetylase 1 (show HDAC1 Antibodies)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.

  3. study characterizes three functional promoters in the human HLCS gene

  4. HLCS interacts physically with the DNA methyltransferase (show DNMT1 Antibodies) DNMT1 (show DNMT1 Antibodies) and the methyl CpG binding protein MeCP2 (show MECP2 Antibodies) to facilitate the binding of HLCS to chromatin.

  5. This study showed that modification of HSP72 (show HSPA1A Antibodies) and demonstrated that binding of biotin to extracellular HSP72 (show HSPA1A Antibodies) prepares cells for a strong immune response.

  6. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype

  7. HLCS methionine-58 is a functional translation start site in human cells.

  8. Holocarboxylase synthetase interacts directly with histone H3 (show HIST3H3 Antibodies), causing biotinylation of lysine K9 and K18 (show KRT18 Antibodies).

  9. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population

  10. The results of this study suggest that miR (show MLXIP Antibodies)-539 is among the factors sensing biotin and regulating holocarboxylase synthetase expression.

Biotin-Protein Ligase (HLCS) Antigen Profile

Protein Summary

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with HLCS

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs) antibody
  • holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (HLCS) antibody
  • holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (Hlcs) antibody
  • 410I21.SP6 antibody
  • D16Jhu34 antibody
  • HCS antibody
  • RGD1565360 antibody

Protein level used designations for HLCS

biotin apo-protein ligase , biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase , biotin--protein ligase , biotin--[acetyl-CoA-carboxylase] ligase , biotin--[methylcrotonoyl-CoA-carboxylase] ligase , biotin--[methylmalonyl-CoA-carboxytransferase] ligase , holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) , holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

GENE ID SPECIES
110948 Mus musculus
3141 Homo sapiens
288240 Rattus norvegicus
Selected quality suppliers for anti-Biotin-Protein Ligase (HLCS) Antibodies
Did you look for something else?