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Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. Additionally we are shipping BLMH Antibodies (85) and BLMH Proteins (23) and many more products for this protein.
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Blmh interacts with diverse cellular processes--lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses--that are essential for normal kidney homeostasis.
Bleomycin hydrolase protects against neurodegeneration associated with elevated homocysteine thiolactone levels in hyperhomocysteinemia and Alzheimer's disease.
bleomycin hydrolase functions as an MHC class I epitope-processing protease
BH does not play a major role either in generating or destroying class I major histocompatibility antigen (MHC)-presented peptides that bind to the MHC in living cells. These results point to redundant functions between peptidases.
Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of filaggrin (show FLG ELISA Kits) gene mutations
This study findings suggest that Blmh interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis.
We also detected significant association between XRCC1 (show XRCC1 ELISA Kits), XRCC3 (show XRCC3 ELISA Kits), and BLHX polymorphisms and a high frequency of chromosomal damage
The caspase (show CASP3 ELISA Kits)-dependent cleavage of BLH was confirmed by cleavage of partly-purified human bleomycin hydrolase with caspase-3 (show CASP3 ELISA Kits).
present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC (show FAM126A ELISA Kits)
This first report on BLMH carrier status in Tunisia shows o association between carrying the BLMH-G genotype and Alzheimer's disease in epsilon4 negative or positive subjects.
Cysteine proteases bleomycin hydrolase and cathepsin Z (show CTSZ ELISA Kits) mediate N-terminal proteolysis and toxicity of mutant huntingtin (show HTT ELISA Kits).
BH activity and expression were markedly decreased in AD lesional skin, suggesting a defect of the filaggrin (show FLG ELISA Kits) degradation pathway in AD.
The homozygous variant G/G of BLMH gene SNP A1450G is associated with reduced survival and higher prevalence of early relapses in TC patients treated with bleomycin-containing chemotherapy.
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
, bleomycin hydrolase
, BLM hydrolase
, aminopeptidase H