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Bone Morphogenetic Protein 4 Proteins (BMP4)

The protein encoded by BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. Additionally we are shipping BMP4 Antibodies (271) and BMP4 Kits (107) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BMP4 652 P12644
BMP4 12159 P21275
BMP4 25296  
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Top BMP4 Proteins at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$546.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   2 μg Log in to see 10 to 12 Days
$86.96
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$1,265.25
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$233.72
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-MBP 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 100 μg Log in to see 5 to 7 Days
$467.78
Details

BMP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced BMP4 Proteins

  1. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2667382 : Labeur, Páez-Pereda, Haedo, Arzt, Stalla: Pituitary tumors: cell type-specific roles for BMP-4. in Molecular and cellular endocrinology 2010 (PubMed)
    Show all 6 references for ABIN2667382

  2. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666448 : Haubold, Weise, Stephan, Dünker: Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. in International journal of biological sciences 2010 (PubMed)
    Show all 5 references for ABIN2666448

  3. Mouse (Murine) BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666446 : Chen, Zhao, Mundy: Bone morphogenetic proteins. in Growth factors (Chur, Switzerland) 2004 (PubMed)
    Show all 4 references for ABIN2666446

  4. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN666737 : Li, Zhang, Xu, Zhang, Kang, Zhao: Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1. in The Journal of trauma 2009 (PubMed)
    Show all 2 references for ABIN666737

  5. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN413086 : Riesco, Valcarce, Alfonso, Herráez, Robles: In vitro generation of zebrafish PGC-like cells. in Biology of reproduction 2014 (PubMed)

More Proteins for Bone Morphogenetic Protein 4 (BMP4) Interaction Partners

Zebrafish Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Structures of Bmp2a (show BMP2 Proteins), Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.

  2. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a (show GREM1 Proteins).

  3. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development.

  4. BMP2b signaling in zebrafish embryos substantially decreases emergence of lymphatic endothelial cells.

  5. Data show that BMP2B protein is expressed in a gradient as early as blastula stages.

  6. we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart

  7. The Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity.

  8. bmp2b is involved in dorsal retina initiation, acting upstream of gdf6a.

  9. Results show that BMP2b down-regulates fshr (show FSHR Proteins) while up-regulating lhr (show LHCGR Proteins).

  10. These data reveal a novel role for LRP1 (show LRP1 Proteins) in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.

Xenopus laevis Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.

  2. Osr1 (show OSR1 Proteins)/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.

  3. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.

  4. PIAS (show PIAS1 Proteins) proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8 (show WNT8A Proteins).

  5. Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.

  6. BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.

  7. Data suggest that the feedback inhibitors BAMBI (show BAMBI Proteins), SMAD6 (show SMAD6 Proteins), and SMAD7 (show SMAD7 Proteins) expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.

  8. limits homeobox (show PRRX1 Proteins) gene expression in the organiser/non-organiser direction

  9. X-epilectin expression is down-regulated by Noggin (show NOG Proteins) and tBR and that this effect is inhibited by BMP4 over-expression

  10. BMP4-dependent expression of Xenopus Grainyhead-like 1 (show GRHL1 Proteins) has a critical role in epidermal differentiation

Horse (Equine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1 (show SMAD1 Proteins)/5 pathway

Human Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.

  2. BMP4 caused a trend towards accelerated metastasis formation, especially in bone. More work is needed to uncover the long-term effects of BMP4 and the clinical relevance of these findings.

  3. BMP4 is a direct thyroid hormone (show PTH Proteins) target and is involved in a positive autoregulatory feedback loop that modulates thyroid hormone (show PTH Proteins) signaling

  4. An up-regulated expression of BMP-4 and BMPR-II (show BMPR2 Proteins) was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 and BMPR-II (show BMPR2 Proteins) expressions were found to be correlated

  5. PDGF (show PDGFA Proteins)-AA impairs endothelium-dependent vasodilation and PDGF (show PDGFA Proteins)-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1 (show GARS Proteins)/5- and SMAD4 (show SMAD4 Proteins)-dependent mechanisms.

  6. BMP4 gene is involved in the ATO regulation of adipogenic and osteogenic differentiation balance, which provides a new target for the treatment of AA

  7. Overexpression of the BMP4/SMAD4 (show SMAD4 Proteins)/SMAD5 (show SMAD5 Proteins) signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  8. HIF-1alpha (show HIF1A Proteins) knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha (show HIF1A Proteins) or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2 (show CA2 Proteins)+)]i.

  9. The effect of TGF-beta1 (show TGFB1 Proteins) and BMP-4 on bone marrow-derived stem cell morphology on a novel bioabsorbable nanocomposite material.

  10. Suggest that hypermethylation of ACP1 (show ACP1 Proteins), BMP4, and TSPYL5 (show TSPYL5 Proteins) are common events in HCC (show FAM126A Proteins) and could be used as potentially detectable biomarkers in HCC (show FAM126A Proteins) tissues.

Mouse (Murine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Ino80 represses Bmp4 expression during embryonic stem cell differentiation.

  2. only BMP7 (show BMP7 Proteins), not BMP2 (show BMP2 Proteins) or BMP4, is necessary for interdigital programmed cell death

  3. Report phenotype of BMP2/4 double knockout osteoblast cell line.

  4. PDGF (show PDGFA Proteins)-AA impairs endothelium-dependent vasodilation and PDGF (show PDGFA Proteins)-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1 (show SMAD1 Proteins)/5- and SMAD4 (show SMAD4 Proteins)-dependent mechanisms.

  5. BMP4 has a role in inducing NOX1 (show NOX1 Proteins)-dependent eNOS (show NOS3 Proteins) uncoupling in T2DM, which may promote development of novel therapeutics restoring endothelial function in T2DM

  6. resveratrol markedly amplifies BMP4induced OPG (show TNFSF11 Proteins) mRNA expression.

  7. BMP4 promotes activation of FGF7 (show FGF7 Proteins) and FGF10 (show FGF10 Proteins) signaling, leading to an increase in proliferative basal cell population in developing skin.

  8. calbindin1 in rat primary islet cells reduced glucose-stimulated insulin (show INS Proteins) secretion (GSIS), and the effect of BMP4 on GSIS was lost in islets from calbindin1 (Calb1 (show CALB1 Proteins)) knockout mice

  9. the dental follicle participates in alveolar bone formation and Bmp2/4 appears to accelerate alveolar bone development

  10. Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.

Cow (Bovine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 (show SLC6A8 Proteins) cell growth

  2. BMP4 during maturation increased the proportion of Oct-4 (show POU5F1 Proteins) positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.

  3. analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene

  4. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation

  5. Data report that BMP-7 (show BMP7 Proteins) suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (show DFFB Proteins)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.

  6. Heat shock protein 70 (show HSP70 Proteins) enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein (show MGP Proteins).

Goat Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. A microsatellite (ACn (show ACIN1 Proteins)) was identified in the 3' UTR of BMP4 gene.Prolificacy associated microsatellite (AC19 (show POLR1D Proteins)) was detected in Indian goats.

Pig (Porcine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. paracrine signals from the embryo, represented by FGF4 (show FGF4 Proteins) and BMP4, induce a response in the trophoblast prior to the extensive elongation.

  2. The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.

  3. Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 Proteins) and ICAM-1 (show ICAM1 Proteins) in a BMP-4- and TGF-beta1 (show TGFB1 Proteins)-dependent pathway.

Rabbit Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. The TM-induced characteristic changes in the expression pattern of Hoxa11 (show HOXA11 Proteins) and Bmp4 on GDs (show PAEP Proteins) 10 and/or 11 were not noted.

  2. BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.

  3. Data show that BMP-2 (show BMP2 Proteins), BMP-4, and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin (show CHRD Proteins) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

  4. Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.

BMP4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Gene names and symbols associated with BMP4

  • bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (bmp4-a)
  • bone morphogenetic protein 4 (BMP4)
  • Bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (LOC100286408)
  • bone morphogenetic protein 2b (bmp2b)
  • bone morphogenetic protein 4 (bmp4-b)
  • bone morphogenetic protein 4 (Bmp4)
  • bmp-2 protein
  • BMP-4 protein
  • bmp2 protein
  • bmp2-4 protein
  • Bmp2b protein
  • Bmp2b-1 protein
  • Bmp2b1 protein
  • BMP4 protein
  • BOMPR4A protein
  • cb670 protein
  • MCOPS6 protein
  • OFC11 protein
  • XBMP-4 protein
  • xbmp4 protein
  • zbmp-2 protein
  • zbmp-4 protein
  • zbmp2 protein
  • zgc:100779 protein
  • ZYME protein

Protein level used designations for BMP4

etID309887.17 , bone morphogenetic protein-4 , bone morphogenetic protein 4 , bone morphogenetic protein 4, isoform 3 , Bone morphogenetic protein 4 , bone morphogenetic protein 4-like , bone morphogenetic protein 2 , etID309839.20 , swirl , swr , BMP-2B , BMP-4 , bone morphogenetic protein 2B

GENE ID SPECIES
30612 Danio rerio
397874 Xenopus laevis
452912 Pan troglodytes
549788 Xenopus (Silurana) tropicalis
100034048 Equus caballus
100049354 Oryzias latipes
100137596 Papio anubis
100194815 Salmo salar
100221891 Taeniopygia guttata
100398270 Callithrix jacchus
100286408 Salmo salar
100449444 Pongo abelii
30632 Danio rerio
652 Homo sapiens
399322 Xenopus laevis
12159 Mus musculus
25296 Rattus norvegicus
407216 Bos taurus
490695 Canis lupus familiaris
100860789 Capra hircus
100113425 Sus scrofa
396165 Gallus gallus
100009569 Oryctolagus cuniculus
100733516 Cavia porcellus
443502 Ovis aries
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