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BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. Additionally we are shipping Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) Antibodies (115) and Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) Proteins (16) and many more products for this protein.
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bmpr2b mediates BMP signaling and is required to establish left-right asymmetry.
An up-regulated expression of BMP-4 (show BMP4 ELISA Kits) and BMPR-II was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 (show BMP4 ELISA Kits) and BMPR-II expressions were found to be correlated
establish the feasibility of combining NELL-1 (show NELL1 ELISA Kits) with BMP2 (show BMP2 ELISA Kits) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (show WNT2 ELISA Kits) pathway activity during NELL-1 (show NELL1 ELISA Kits) and BMP2 (show BMP2 ELISA Kits) osteogenesis
Raf (show RAF1 ELISA Kits) family members and ERK1/2 (show MAPK1/3 ELISA Kits) were constitutively activated after BMPR2 knockdown
miR (show MLXIP ELISA Kits)-153 is a mechano-sensitive miRNA that regulates osteoblast differentiation by directly targeting BMPR2, and that therapeutic inhibition of miR (show MLXIP ELISA Kits)-153 may be an efficient anabolic strategy for skeletal disorders caused by pathological mechanical loading.
BMP-2 (show BMP2 ELISA Kits) and -4 are produced by vascular smooth muscle cells in atherosclerotic lesions and induce monocyte chemotaxis through direct BMPRII activation
study shows for the first time that in the regulatory region of the BMPR2 gene the promoter may be important for pulmonary arterial hypertension penetrance
Correlations between C23 (show NCL ELISA Kits), BMPRII expression and prognosis of gastric cancer patients.
local gene transfection can up-regulate the expression of osteogenic mediators (BMP-2 (show BMP2 ELISA Kits) and TGF-beta1 (show TGFB1 ELISA Kits)), which may promote cell differentiation and proliferation and stimulate extracellular matrix synthesis and new bone formation in distraction gap.
BMP2 (show BMP2 ELISA Kits) decreased serum-induced proliferation and increased the pro-apoptotic Bax (show BAX ELISA Kits)/Bcl-2 (show BCL2 ELISA Kits) ratio. These effects were attenuated by endothelin-1 (show EDN1 ELISA Kits) pre-treatment
our results showed that GDF-5 (show GDF5 ELISA Kits) and BMPRII expressed both in normal and degenerated intervertebral disc tissues, and GDF-5 (show GDF5 ELISA Kits) might have an inhibition effect on degenerated lumbar intervertebral discs
Deleting Bmpr2 in mouse skeletal progenitor cells impaired activin (show Actbeta ELISA Kits) signaling resulting in an increased bone formation rate and high bone mass.
The findings suggest that the mutant ALK2 (show ACRV1 ELISA Kits) related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2 (show ACRV1 ELISA Kits).
BMPR2 has tumor suppressive functions in the stroma by regulating inflammation.
Serotonin can increase ERalpha (show ESR1 ELISA Kits) expression in human pulmonary arterial smooth muscle cells and antagonism of oestrogen receptor alpha reverses serotonin-dependent PH in the mouse and increases bone morphogenetic protein receptor type 2 expression
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.
Members of the miR-17 family influence gastrulation by suppressing Bmpr2 expression at the primitive streak.
Bmp4 (show BMP4 ELISA Kits), Bmp7 (show BMP7 ELISA Kits) and bmpr2 signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo
Mutations in BMPR2 underlie most heritable cases and a small proportion of sporadic cases of idiopathic pulmonary arterial hypertension.
BMP9 (show GDF2 ELISA Kits) is identified as the preferred ligand for preventing apoptosis and enhancing monolayer integrity in endothelial cells from subjects with pulmonary arterial hypertension who bear mutations in the gene encoding BMPR2.
These data suggest that heterozygous null BMPR2 mutations promote SRC (show SRC ELISA Kits)-dependent caveolar trafficking defects in PECs and that this may contribute to pulmonary endothelial barrier dysfunction in Hereditary pulmonary arterial hypertension patients
Report temporal regulation of BMPR2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Losartan therapy was associated with persistent overexpressions of ANG II (show AGT ELISA Kits), AT2 (show AGTR2 ELISA Kits), ET-1 (show EDN1 ELISA Kits), ETB (show EDNRB ELISA Kits), and angiopoietin-1 (show ANGPT1 ELISA Kits) and with a return to normal of the BMPR-2 expression.
Stimulation of BMPRII promotes normal pulmonary artery endothelial cell function by activating eNOS (show NOS3 ELISA Kits).
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
bone morphogenetic protein receptor type II
, bone morphogenetic protein receptor type-2
, bone morphogenetic protein receptor type II b
, BMP type II receptor
, BMP type-2 receptor
, type II activin receptor-like kinase
, type II receptor for bone morphogenetic protein-4
, bone morphogenic protein receptor, type II (serine/threonine kinase)
, bone morphogenic protein receptor type 2