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Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) Proteins (BMPR2)

BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. Additionally we are shipping BMPR2 Antibodies (132) and BMPR2 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BMPR2 659 Q13873
BMPR2 12168 O35607
Rat BMPR2 BMPR2 140590  
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Top BMPR2 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$272.80
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Human Cells Human Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$272.80
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HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
$203.50
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HOST_Human Human Fc Tag,His tag   10 μg Log in to see 11 Days
$137.50
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HOST_HEK-293 Cells Human Fc Tag,His tag   50 μg Log in to see 12 to 15 Days
$160.55
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HOST_Baculovirus infected Insect Cells Human His tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
Insect Cells Human His tag   10 μg Log in to see 3 to 4 Days
$310.00
Details

BMPR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine)
,

Top referenced BMPR2 Proteins

  1. Human BMPR2 Protein expressed in Human Cells - ABIN2003034 : Feng, Liu, Liu, Liu, Liang, Li: [Foreign body in tracheobronchial diagnosed as pneumonia from children]. in Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 2006 (PubMed)
    Show all 6 references for ABIN2003034

  2. Human BMPR2 Protein expressed in Wheat germ - ABIN1346791 : Miyagi, Mikawa, Hasegawa, Kobayashi, Sho, Matsuyama, Sato: Bone morphogenetic protein receptor expressions in the adult rat brain. in Neuroscience 2011 (PubMed)

More Proteins for Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) Interaction Partners

Zebrafish Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) interaction partners

  1. bmpr2b mediates BMP signaling and is required to establish left-right asymmetry.

Human Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) interaction partners

  1. In solid ameloblastoma, positive correlations were observed between the stromal and parenchymal expression of BMP-2 (show BMP2 Proteins) and between the stromal expression of BMP-2 (show BMP2 Proteins) and BMP-4 (show BMP4 Proteins), as well as between the stromal expression of BMPR-II and BMP-4 (show BMP4 Proteins) and the stromal and parenchymal expression of BMPR-II.

  2. In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 19 mutations found in BMPR2.

  3. Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6 (show BMP6 Proteins), ALK2 (show ACRV1 Proteins) and BMPRII had deeper growth than tumors with only BMP6 (show BMP6 Proteins) expression

  4. Case Report: sarcoid-like reaction due to pulmonary hypertension in the context of the BMPR2 mutation.

  5. The genetic-interactions among BMPR-2, ALK-1 (show ACVRL1 Proteins), and 5-HTT (show SLC6A4 Proteins) polymorphisms, elevated BMP-2 (show BMP2 Proteins) and 5-HT (show DDC Proteins) levels and differential gene expression substantiated the strong genetic contribution in high altitude pulmonary edema pathophysiology.

  6. Patients with pulmonary arterial hypertension and bone morphogenetic protein receptor type II mutations present at a younger age with more severe disease, and are at increased risk of death, and death or transplantation, compared with those without BMPR2 mutations.

  7. Study of four patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection found predisposing mutations in the BMPR2, ACVRL1 (show ACVRL1 Proteins) and ENG (show ENG Proteins) genes.

  8. BMPR2 mutations were identified in congenital heart disease-pulmonary vascular disease patients, with missense mutation of BMPR2 as the dominant mutation type.

  9. his study demonstrated that both rs6435156C > T and rs1048829G > T variants in BMPR2 contributed to increased susceptibility to hronic obstructive pulmonary disease

  10. Increased HMGA1 (show HMGA1 Proteins) in pulmonary arterial endothelial cells resulting from dysfunctional BMPR2 signaling can transition endothelium to smooth muscle-like cells associated with pulmonary arterial hypertension.

Mouse (Murine) Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) interaction partners

  1. BMPR2 gene transfer reduced TGF-beta effects on Smad2, Smad1/5/8 and Erk1/2 phosphorylation in human pulmonary arterial smooth muscle cells

  2. Deleting Bmpr2 in mouse skeletal progenitor cells impaired activin signaling resulting in an increased bone formation rate and high bone mass.

  3. The findings suggest that the mutant ALK2 (show ACRV1 Proteins) related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2 (show ACRV1 Proteins).

  4. BMPR2 has tumor suppressive functions in the stroma by regulating inflammation.

  5. Serotonin can increase ERalpha (show ESR1 Proteins) expression in human pulmonary arterial smooth muscle cells and antagonism of oestrogen receptor alpha reverses serotonin-dependent PH in the mouse and increases bone morphogenetic protein receptor type 2 expression

  6. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.

  7. Members of the miR-17 family influence gastrulation by suppressing Bmpr2 expression at the primitive streak.

  8. Bmp4 (show BMP4 Proteins), Bmp7 (show BMP7 Proteins) and bmpr2 signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

  9. Mutations in BMPR2 underlie most heritable cases and a small proportion of sporadic cases of idiopathic pulmonary arterial hypertension.

  10. BMP9 (show GDF2 Proteins) is identified as the preferred ligand for preventing apoptosis and enhancing monolayer integrity in endothelial cells from subjects with pulmonary arterial hypertension who bear mutations in the gene encoding BMPR2.

Pig (Porcine) Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) interaction partners

  1. Report temporal regulation of BMPR2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  2. Losartan therapy was associated with persistent overexpressions of ANG II (show AGT Proteins), AT2 (show AGTR2 Proteins), ET-1 (show EDN1 Proteins), ETB (show EDNRB Proteins), and angiopoietin-1 (show ANGPT1 Proteins) and with a return to normal of the BMPR-2 expression.

Cow (Bovine) Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) interaction partners

  1. Stimulation of BMPRII promotes normal pulmonary artery endothelial cell function by activating eNOS (show NOS3 Proteins).

BMPR2 Protein Profile

Protein Summary

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

Gene names and symbols associated with BMPR2

  • bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)
  • bone morphogenetic protein receptor, type II b (serine/threonine kinase) (bmpr2b)
  • bone morphogenetic protein receptor, type II (serine/threonine kinase) (Bmpr2)
  • 2610024H22Rik protein
  • AL117858 protein
  • AW546137 protein
  • BB189135 protein
  • BMP-2 protein
  • BMPR-2 protein
  • Bmpr-II protein
  • BMPR3 protein
  • bmprii protein
  • BMR2 protein
  • BRK-3 protein
  • Gm20272 protein
  • PPH1 protein
  • T-ALK protein

Protein level used designations for BMPR2

bone morphogenetic protein receptor type II , bone morphogenetic protein receptor type-2 , bone morphogenetic protein receptor type II b , BMP type II receptor , BMP type-2 receptor , BMPR-2 , type II activin receptor-like kinase , type II receptor for bone morphogenetic protein-4 , bone morphogenic protein receptor, type II (serine/threonine kinase) , bone morphogenic protein receptor type 2

GENE ID SPECIES
459885 Pan troglodytes
555655 Danio rerio
659 Homo sapiens
12168 Mus musculus
140590 Rattus norvegicus
374147 Gallus gallus
100127483 Sus scrofa
407127 Bos taurus
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