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The protein encoded by BRP44L is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. Additionally we are shipping Brain Protein 44-Like Antibodies (31) and Brain Protein 44-Like Kits (5) and many more products for this protein.
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GTPBP3 (show GTPBP3 Proteins) plays a role in the regulation of MCP1 (show CCL2 Proteins) protein through AMPK (show PRKAA1 Proteins) signaling.
Tumor cells expressing MPC1 and MPC2 (show BRP44 Proteins) display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture.
genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 (show BRP44 Proteins) form an essential part of the mitochondrial pyruvate carrier
Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.
brain protein 44-like
, brain protein 44-like protein a
, brain protein 44-like protein b
, brain protein 44-like protein
, putative brain protein 44-like variant 2
, mitochondrial pyruvate carrier 1
, HSPC040 protein
, apoptosis-regulating basic protein