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may be involved in apoptosis of neuronal cells. Additionally we are shipping Brain Protein 44-Like Kits (6) and Brain Protein 44-Like Proteins (4) and many more products for this protein.
Showing 10 out of 32 products:
Human Polyclonal BRP44L Primary Antibody for WB - ABIN2801962
Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. in Genome research 2000
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Human Polyclonal BRP44L Primary Antibody for ICC, IF - ABIN4285411
Konstantakou, Voutsinas, Velentzas, Basogianni, Paronis, Balafas, Kostomitsopoulos, Syrigos, Anastasiadou, Stravopodis: 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants. in Molecular cancer 2015
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Human Polyclonal BRP44L Primary Antibody for IF, IHC - ABIN1534701
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA (show LPCAT2 Antibodies) formation.
GTPBP3 (show GTPBP3 Antibodies) plays a role in the regulation of MCP1 (show CCL2 Antibodies) protein through AMPK (show PRKAA1 Antibodies) signaling.
Tumor cells expressing MPC1 and MPC2 (show BRP44 Antibodies) display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture.
genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 (show BRP44 Antibodies) form an essential part of the mitochondrial pyruvate carrier
Our study indicates that MPC1 and MPC2 (show CBX4 Antibodies) expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 (show CBX4 Antibodies) is a predictor of favorable outcome.
Results show that Mpc1 is required for mammalian embryonic development and efficient pyruvate metabolism.
This resulted in embryonic lethality at around E13.5. Mouse embryonic fibroblasts (MEFs) derived from mutant mice displayed defective pyruvate-driven respiration as well as perturbed metabolic profiles, and both defects could be restored by reexpression of MPC1.
Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.
brain protein 44-like
, brain protein 44-like protein a
, brain protein 44-like protein b
, brain protein 44-like protein
, putative brain protein 44-like variant 2
, mitochondrial pyruvate carrier 1
, HSPC040 protein
, apoptosis-regulating basic protein