Brain Protein 44-Like Proteins (BRP44L)

The protein encoded by BRP44L is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. Additionally we are shipping Brain Protein 44-Like Antibodies (32) and Brain Protein 44-Like Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRP44L 51660 Q9Y5U8
BRP44L 55951 P63030
Rat BRP44L BRP44L 171087 P63031
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Top Brain Protein 44-Like Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 15 to 18 Days
$733.00
Details

BRP44L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Brain Protein 44-Like (BRP44L) Interaction Partners

Human Brain Protein 44-Like (BRP44L) interaction partners

  1. Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA (show LPCAT2 Proteins) formation.

  2. GTPBP3 (show GTPBP3 Proteins) plays a role in the regulation of MCP1 (show CCL2 Proteins) protein through AMPK (show PRKAA1 Proteins) signaling.

  3. Tumor cells expressing MPC1 and MPC2 (show BRP44 Proteins) display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture.

  4. genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 (show BRP44 Proteins) form an essential part of the mitochondrial pyruvate carrier

Mouse (Murine) Brain Protein 44-Like (BRP44L) interaction partners

  1. Results show that Mpc1 is required for mammalian embryonic development and efficient pyruvate metabolism.

  2. This resulted in embryonic lethality at around E13.5. Mouse embryonic fibroblasts (MEFs) derived from mutant mice displayed defective pyruvate-driven respiration as well as perturbed metabolic profiles, and both defects could be restored by reexpression of MPC1.

  3. Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.

Brain Protein 44-Like (BRP44L) Protein Profile

Protein Summary

The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.

Gene names and symbols associated with Brain Protein 44-Like Proteins (BRP44L)

  • brain protein 44-like (brp44l)
  • brain protein 44-like (brp44l-a)
  • brain protein 44-like (LOC542696)
  • brain protein 44-like (BRP44L)
  • brain protein 44-like (brp44l-b)
  • brain protein 44-like (LOC100164048)
  • brain protein 44-like (LOC100167201)
  • brain protein 44-like (LOC100190286)
  • mitochondrial pyruvate carrier 1 (MPC1)
  • mitochondrial pyruvate carrier 1 (Mpc1)
  • 0610006G08Rik protein
  • 3830411I18Rik protein
  • Brp44l protein
  • brp44la protein
  • brp44lb protein
  • CGI-129 protein
  • dJ68L15.3 protein
  • MGC64469 protein
  • MGC90013 protein
  • MPC1 protein
  • MPYCD protein

Protein level used designations for Brain Protein 44-Like Proteins (BRP44L)

brain protein 44-like , brain protein 44-like protein a , brain protein 44-like protein b , brain protein 44-like protein , putative brain protein 44-like variant 2 , mitochondrial pyruvate carrier 1 , HSPC040 protein , apoptosis-regulating basic protein

GENE ID SPECIES
448739 Xenopus (Silurana) tropicalis
496160 Xenopus laevis
542696 Zea mays
737234 Pan troglodytes
780760 Xenopus laevis
100164048 Acyrthosiphon pisum
100167201 Acyrthosiphon pisum
100190286 Taeniopygia guttata
767977 Bos taurus
428592 Gallus gallus
609356 Canis lupus familiaris
51660 Homo sapiens
55951 Mus musculus
171087 Rattus norvegicus
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