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anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRE Proteins (12) and BRE Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BRE 9577 Q9NXR7
BRE 362704 Q6P7Q1
BRE 107976 Q8K3W0
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Top anti-BRE Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IP, WB WB Image BRCC45 antibody detects BRE protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract B. 30 µg A431 whole cell lysate/extract 10 % SDS-PAGE BRCC45 antibody , dilution: 1:1000 IP Image BRE antibody immunoprecipitates BRE protein in IP experiments. IP Sample: 1000 μg 293T whole cell lysate/extract A. Control with 2.5 μg of preimmune rabbit IgG B. Immunoprecipitation of BRE protein by 2.5 μg of BRE antibody , 10% SDS-PAGE The immunoprecipitated BRE protein was detected by BRE antibody , diluted at 1:1000. EasyBlot anti-rabbit IgG  was used as a secondary reagent. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image BRCC45 antibody detects BRCC45 protein at nucleus and cytosol on rat middle brain by immunohistochemical analysis. Sample: Paraffin-embedded rat middle brain. BRCC45 antibody , dilution: 1:500. IHC-P Image BRCC45 antibody detects BRCC45 protein at nucleus and cytosol on mouse colon by immunohistochemical analysis. Sample: Paraffin-embedded mouse colon. BRCC45 antibody , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Placenta (formalin-fixed, paraffin-embedded) stained with BRE antibody ABIN343906 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 μg/ml. Western blot analysis of BRCC45 in HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with AP30165PU-N BRCC45 antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$455.07
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using BRE antibody at 1/200 dilution. Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details

BRE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus) , ,


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Mouse (Murine) , ,


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Top referenced anti-BRE Antibodies

  1. Human Polyclonal BRE Primary Antibody for WB - ABIN2801968 : Li, Yoo, Becker, Ali-Osman, Chan: Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. in Biochemical and biophysical research communications 1995 (PubMed)
    Show all 4 references for ABIN2801968

  2. Human Polyclonal BRE Primary Antibody for IHC, ELISA - ABIN1001939 : Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003 (PubMed)
    Show all 3 references for ABIN1001939

More Antibodies against BRE Interaction Partners

Human Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) interaction partners

  1. High BRE and high EVI1 (show MECOM Antibodies) expression are mutually exclusive in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-positive acute myeloid leukemia (show BCL11A Antibodies) patients.

  2. High BRE expression defines a novel subtype of adult acute myeloid leukemia (show BCL11A Antibodies) characterized by a favorable prognosis.

  3. NBA1/MERIT40 (show BABAM1 Antibodies) and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Antibodies)-containing complexes

  4. overexpression of the BRE gene is predominantly found in MLL (show MLL Antibodies)-rearranged AML (show RUNX1 Antibodies) with t(9;11)(p22 (show DYNC1H1 Antibodies);q23).

  5. A novel stress-responsive gene called BRE which interacts with TNF (show TNF Antibodies)-receptor-1 and blocks the apoptotic effect of TNF-alpha (show TNF Antibodies), was identified.

  6. These results show that BRE over-expression can indeed promote growth, though not initiation, of liver tumors.

  7. BRE mediates antiapoptosis by inhibiting the mitochondrial apoptotic machinery

  8. the enhanced tumor growth is more likely due to the antiapoptotic activity of BRE than any direct effect of the protein on cell proliferation

  9. Antiapoptotic in vivo; Bre levels are regulated post-transcriptionally in the liver, which is not observed in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and non-HCC (show FAM126A Antibodies) cell lines.

  10. results implied that BRE plays a significant role in mediating antiapoptotic and proliferative responses in esophageal carcinoma cells

Mouse (Murine) Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) interaction partners

  1. Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth.

  2. BRE has a role in the regulation of key proteins of the cellular stress-response machinery, including prohibitin (show PHB Antibodies) and p53 (show TP53 Antibodies)

BRE Antigen Profile

Protein Summary

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).

Gene names and symbols associated with BRE

  • brain and reproductive organ-expressed (TNFRSF1A modulator) (bre) antibody
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE) antibody
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (LOC100231620) antibody
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (LOC100347469) antibody
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (Bre) antibody
  • brain and reproductive organ-expressed protein (Bre) antibody
  • brain and reproductive organ-expressed protein (bre) antibody
  • 6030405P19Rik antibody
  • AI429776 antibody
  • B830038C02Rik antibody
  • BRCC4 antibody
  • BRCC45 antibody
  • BRE antibody
  • im:7141046 antibody
  • LOC100231620 antibody
  • zgc:110368 antibody

Protein level used designations for BRE

BRCA1-A complex subunit BRE , BRCA1/BRCA2-containing complex subunit 45 , Brain and reproductive organ-expressed protein , brain and reproductive organ-expressed (TNFRSF1A modulator) , BRCA1-A complex subunit BRE-like , BRCA1/BRCA2-containing complex, subunit 4 , brain and reproductive organ-expressed protein

GENE ID SPECIES
448242 Xenopus (Silurana) tropicalis
459112 Pan troglodytes
475711 Canis lupus familiaris
702365 Macaca mulatta
100231620 Taeniopygia guttata
100347469 Oryctolagus cuniculus
100396239 Callithrix jacchus
100583596 Nomascus leucogenys
9577 Homo sapiens
362704 Rattus norvegicus
614152 Bos taurus
421417 Gallus gallus
100171610 Pongo abelii
444077 Xenopus laevis
107976 Mus musculus
550474 Danio rerio
Selected quality suppliers for anti-BRE (BRE) Antibodies
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