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BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. Additionally we are shipping BCAT1 Antibodies (85) and BCAT1 Kits (1) and many more products for this protein.
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Human BCAT1 Protein expressed in Escherichia coli (E. coli) - ABIN1098597
Schuldiner, Eden, Ben-Yosef, Yanuka, Simchen, Benvenisty: ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. in Proceedings of the National Academy of Sciences of the United States of America 1996
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BCAT1 is strongly overexpressed in ovarian cancer.
Focal deletions of the BCAT1 were associated with B-cell precursor acute lymphoblastic leukemia.
levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 (show RPS19 Proteins) and RPL11 (show RPL11 Proteins) cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations
Over-expression of BCAT1, a c-Myc (show MYC Proteins) target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma.
A central role for BCAT1 in glioma pathogenesis, making BCAT1 and branched-chain amino acids metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.
The mitochondrial isoform human brain BCAT 2 (show BCAT2 Proteins) is largely confined to vascular endothelial cells, whereas the cytosolic human brain BCAT 1 is restricted to neurons.
BCATc (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (show BCAT2 Proteins) (mitochondrial). Furthermore, the CXXC motif of BCATc was estimated to be 80 mV lower, suggesting that BCATm (show BCAT2 Proteins) is more oxidizing in nature.
Our results suggest that ECA39 is a dominant predictive factor for distant metastasis in patients with advanced colorectal cancer (CRC (show CALR Proteins)).
The BCAT1 identified in the amplified 12p11-p12 (show POLE4 Proteins) region may play a certain role in nasopharyngeal carcinoma development.
hBCATc has redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for hBCATc in cellular redox control
results suggest transcriptional adaptations occur in BCATm (show BCAT2 Proteins) KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes
BCATc as a novel regulator of T cell activation and metabolism
leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 (show BCAT2 Proteins) and BCKDK (show BCKDK Proteins)) that metabolize branched-chain amino acids.
analysis of the biochemical mechanism of BCATm (show BCAT2 Proteins) (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate (show GRIN1 Proteins)
Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6
Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF (show BDNF Proteins) in a time- and region-dependent fashion.
BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.
BCATm (show BCAT2 Proteins)(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin (show INS Proteins) tolerance & protection from diet-induced obesity
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
branched-chain-amino-acid aminotransferase, cytosolic
, branched chain aminotransferase 1, cytosolic
, branched chain amino-acid transaminase 1, cytosolic
, branched-chain-amino-acid aminotransferase, cytosolic-like
, placental protein 18
, cytosolic branched-chain amino acid aminotransferase