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BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. Additionally we are shipping BCAT1 Proteins (12) and many more products for this protein.
Showing 10 out of 91 products:
Guinea Pig Polyclonal BCAT1 Primary Antibody for WB - ABIN610836
Cross, Alessi, Cohen, Andjelkovich, Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. in Nature 1996
Show all 4 references for ABIN610836
Human Monoclonal BCAT1 Primary Antibody for IF, WB - ABIN968446
Ben-Yosef, Yanuka, Benvenisty: ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog, Gcn4, in yeast. in Oncogene 1997
Show all 4 references for ABIN968446
Human Polyclonal BCAT1 Primary Antibody for EIA, IHC (p) - ABIN950617
Eijgelsheim, Newton-Cheh, Sotoodehnia, de Bakker, Müller, Morrison, Smith, Isaacs, Sanna, Dörr, Navarro, Fuchsberger, Nolte, de Geus, Estrada, Hwang, Bis, Rückert, Alonso, Launer, Hottenga, Rivadeneira, Noseworthy, Rice, Perz, Arking, Spector, Kors, Aulch: Genome-wide association analysis identifies multiple loci related to resting heart rate. in Human molecular genetics 2010
Show all 3 references for ABIN950617
Human Polyclonal BCAT1 Primary Antibody for WB - ABIN2782506
Conway, Coles, Islam, Hutson: Regulatory control of human cytosolic branched-chain aminotransferase by oxidation and S-glutathionylation and its interactions with redox sensitive neuronal proteins. in Biochemistry 2008
BCAT1 expression is significantly upregulated in human masticatory mucosa during wound healing
Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L (show DOT1L Antibodies)-mediated sphere formation and cell migration in breast cancer cells
BCAT1 overexpression is associated with advanced tumour status, and implies adverse clinical outcomes of urothelial carcinoma
BCAT1 is strongly overexpressed in ovarian cancer.
Focal deletions of the BCAT1 were associated with B-cell precursor acute lymphoblastic leukemia.
levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 (show RPS19 Antibodies) and RPL11 (show RPL11 Antibodies) cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations
Over-expression of BCAT1, a c-Myc (show MYC Antibodies) target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma.
A central role for BCAT1 in glioma pathogenesis, making BCAT1 and branched-chain amino acids metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.
The mitochondrial isoform human brain BCAT 2 (show BCAT2 Antibodies) is largely confined to vascular endothelial cells, whereas the cytosolic human brain BCAT 1 is restricted to neurons.
BCATc (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (show BCAT2 Antibodies) (mitochondrial). Furthermore, the CXXC motif of BCATc was estimated to be 80 mV lower, suggesting that BCATm (show BCAT2 Antibodies) is more oxidizing in nature.
results suggest transcriptional adaptations occur in BCATm (show BCAT2 Antibodies) KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes
BCATc as a novel regulator of T cell activation and metabolism
leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 (show BCAT2 Antibodies) and BCKDK (show BCKDK Antibodies)) that metabolize branched-chain amino acids.
analysis of the biochemical mechanism of BCATm (show BCAT2 Antibodies) (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate (show GRIN1 Antibodies)
Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6
Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF (show BDNF Antibodies) in a time- and region-dependent fashion.
BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.
BCATm (show BCAT2 Antibodies)(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin (show INS Antibodies) tolerance & protection from diet-induced obesity
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
branched-chain-amino-acid aminotransferase, cytosolic
, branched chain aminotransferase 1, cytosolic
, branched chain amino-acid transaminase 1, cytosolic
, branched-chain-amino-acid aminotransferase, cytosolic-like
, placental protein 18
, cytosolic branched-chain amino acid aminotransferase