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anti-Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Antibodies

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. Additionally we are shipping BCAR3 Kits (9) and BCAR3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCAR3 29815 Q9QZK2
BCAR3 8412 O75815
BCAR3 310838  
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Top anti-BCAR3 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, WB Western blot analysis of BCAR3 in mouse kidney tissue lysate with BCAR3 Antibody  at A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged BCAR3 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IHC (p), WB BCAR3 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method BCAR3 was detected in paraffin-embedded sections of mouse lymphaden tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa/Jurkat cells, using BCAR3 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BCAR3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IP, PLA, WB 0.1 mL Log in to see 5 to 7 Days
$477.75
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated IHC (p) Anti-BCAR3 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1100188 dilution 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details

BCAR3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-BCAR3 Antibodies

  1. Human Monoclonal BCAR3 Primary Antibody for ELISA, WB - ABIN393728 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN393728

  2. Human Polyclonal BCAR3 Primary Antibody for EIA, IF - ABIN1449996 : Riggins, Quilliam, Bouton: Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for ABIN1449996

  3. Mouse (Murine) Polyclonal BCAR3 Primary Antibody for ELISA, WB - ABIN184592 : van Agthoven, van Agthoven, Dekker, van der Spek, Vreede, Dorssers: Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. in The EMBO journal 1998 (PubMed)

More Antibodies against BCAR3 Interaction Partners

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. data presented here suggest that Bcar3 could play a role in testis development

  2. many BCAR3-me (show BCAR1 Antibodies)diated signaling events in epithelial and mesenchymal cells are independent of p130 (show AKT1 Antibodies)Cas association

  3. p130Cas (show BCAR1 Antibodies)- and HEF1 (show NEDD9 Antibodies)-associated AND-34 may regulate B cell adhesion and motility through a Cdc42 (show CDC42 Antibodies)-mediated signaling pathway.

  4. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1 (show NEDD9 Antibodies))

Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. BCAR3 is an essential interactor and mediator of HEF1 (show NEDD9 Antibodies)-induced migration.

  2. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling pathway in invasive breast tumors.

  3. BCAR1 (show BCAR1 Antibodies) and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance

  4. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin (show INS Antibodies) leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 (show SLC2A4 Antibodies) translocation.

  5. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

  6. BCAR3 expression may regulate Src (show SRC Antibodies) signaling in a BCAR3-p130(cas (show BCAR1 Antibodies)) complex-dependent fashion by altering the ability of the Src (show SRC Antibodies) SH3 domain (show ITSN1 Antibodies) to bind the p130(cas (show BCAR1 Antibodies)) SBD (show TRAPPC4 Antibodies)

  7. BCAR3-p130Cas (show BCAR1 Antibodies) complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac (show AKT1 Antibodies) activation or discohesion of epithelial breast cancer cells

  8. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes

  9. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner

  10. BCAR3 and NSP1 (show SH2D3A Antibodies) are more highly expressed than SH2D3C (SHEP1 (show SH2D3C Antibodies)) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

BCAR3 Antigen Profile

Protein Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCAR3

  • breast cancer anti-estrogen resistance 3 (BCAR3) antibody
  • breast cancer anti-estrogen resistance 3 (bcar3) antibody
  • breast cancer anti-estrogen resistance 3 (LOC100219682) antibody
  • breast cancer anti-estrogen resistance 3 (Bcar3) antibody
  • AI131758 antibody
  • AND-34 antibody
  • BCAR3 antibody
  • NSP2 antibody
  • SH2D3B antibody

Protein level used designations for BCAR3

breast cancer anti-estrogen resistance 3 , breast cancer antiestrogen resistance 3 , breast cancer anti-estrogen resistance protein 3 , breast cancer anti-estrogen resistance protein 3-like , p130Cas-binding protein AND-34 , SH2 domain-containing protein 3B , breast cancer antiestrogen resistance 3 protein , dJ1033H22.2 (breast cancer anti-estrogen resistance 3) , novel SH2-containing protein 2

GENE ID SPECIES
424494 Gallus gallus
457032 Pan troglodytes
570610 Danio rerio
100029255 Monodelphis domestica
100059015 Equus caballus
100219682 Taeniopygia guttata
100352424 Oryctolagus cuniculus
100404661 Callithrix jacchus
100447373 Pongo abelii
100475875 Ailuropoda melanoleuca
100036719 Xenopus (Silurana) tropicalis
100593533 Nomascus leucogenys
29815 Mus musculus
8412 Homo sapiens
479941 Canis lupus familiaris
100155981 Sus scrofa
506231 Bos taurus
310838 Rattus norvegicus
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