anti-Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Antibodies

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. Additionally we are shipping BCAR3 Kits (11) and BCAR3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCAR3 8412 O75815
BCAR3 29815 Q9QZK2
BCAR3 310838  
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Top anti-BCAR3 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged BCAR3 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), WB BCAR3 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method BCAR3 was detected in paraffin-embedded sections of mouse lymphaden tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IP, PLA, WB Proximity Ligation Assay: BCAR3 Antibody [ABIN2577373] - Secondary-conjugate Duolink II PLA in Hela cells. goat-anti human FUS (NBP2-14860) and rabbit anti-human BCAR3 (ABIN2577373). Image merged from DAPI (2ms) and Texas Red (200ms) exposures, 40X magnification. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa/Jurkat cells, using BCAR3 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BCAR3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of BCAR3 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Immunohistochemical analysis of BCAR3 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL Log in to see 13 to 14 Days
$487.50
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB   100 μL Log in to see 16 Days
$175.80
Details

BCAR3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BCAR3 Antibodies

  1. Human Monoclonal BCAR3 Primary Antibody for ELISA, WB - ABIN393728 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for 393728

  2. Mouse (Murine) Polyclonal BCAR3 Primary Antibody for ELISA, WB - ABIN184592 : van Agthoven, van Agthoven, Dekker, van der Spek, Vreede, Dorssers: Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. in The EMBO journal 1998 (PubMed)

  3. Human Polyclonal BCAR3 Primary Antibody for IP, PLA - ABIN257737 : Sun, Cheng, Chen, Lim, Pallen: Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. in Molecular and cellular biology 2012 (PubMed)

More Antibodies against BCAR3 Interaction Partners

Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. BCAR3 is an essential interactor and mediator of HEF1 (show NEDD9 Antibodies)-induced migration.

  2. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling pathway in invasive breast tumors.

  3. BCAR1 (show BCAR1 Antibodies) and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance

  4. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin (show INS Antibodies) leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 (show SLC2A4 Antibodies) translocation.

  5. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

  6. BCAR3 expression may regulate Src (show SRC Antibodies) signaling in a BCAR3-p130(cas (show BCAR1 Antibodies)) complex-dependent fashion by altering the ability of the Src (show SRC Antibodies) SH3 domain (show ITSN1 Antibodies) to bind the p130(cas (show BCAR1 Antibodies)) SBD (show TRAPPC4 Antibodies)

  7. BCAR3-p130Cas complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac ac (show BCAR1 Antibodies)tivation or discohesion of epithelial breast cancer cells

  8. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes

  9. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner

  10. BCAR3 and NSP1 (show SH2D3A Antibodies) are more highly expressed than SH2D3C (SHEP1 (show SH2D3C Antibodies)) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. data presented here suggest that Bcar3 could play a role in testis development

  2. many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas (show BCAR1 Antibodies) association

  3. p130Cas (show BCAR1 Antibodies)- and HEF1 (show NEDD9 Antibodies)-associated AND-34 may regulate B cell adhesion and motility through a Cdc42 (show CDC42 Antibodies)-mediated signaling pathway.

  4. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1 (show NEDD9 Antibodies))

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 (show GATA2 Antibodies) during gastrulation, and is co-expressed with gata2 (show GATA2 Antibodies) but is more broadly expressed during later development; its binding partner, bcar1 (show BCAR1 Antibodies) shows overlapping expression patterns

BCAR3 Antigen Profile

Protein Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCAR3

  • breast cancer anti-estrogen resistance 3 (BCAR3) antibody
  • breast cancer anti-estrogen resistance 3 (Bcar3) antibody
  • breast cancer anti-estrogen resistance 3 (bcar3) antibody
  • breast cancer anti-estrogen resistance 3 (LOC100219682) antibody
  • breast cancer anti-estrogen resistance protein 3 homolog (bcar3) antibody
  • AI131758 antibody
  • AND-34 antibody
  • BCAR3 antibody
  • NSP2 antibody
  • SH2D3B antibody

Protein level used designations for BCAR3

SH2 domain-containing protein 3B , breast cancer anti-estrogen resistance protein 3 , breast cancer antiestrogen resistance 3 protein , dJ1033H22.2 (breast cancer anti-estrogen resistance 3) , novel SH2-containing protein 2 , p130Cas-binding protein AND-34 , breast cancer anti-estrogen resistance 3 , breast cancer antiestrogen resistance 3 , breast cancer anti-estrogen resistance protein 3-like

GENE ID SPECIES
8412 Homo sapiens
29815 Mus musculus
310838 Rattus norvegicus
424494 Gallus gallus
457032 Pan troglodytes
479941 Canis lupus familiaris
506231 Bos taurus
570610 Danio rerio
100059015 Equus caballus
100404661 Callithrix jacchus
100447373 Pongo abelii
100219682 Taeniopygia guttata
100029255 Monodelphis domestica
100155981 Sus scrofa
100352424 Oryctolagus cuniculus
100475875 Ailuropoda melanoleuca
100036719 Xenopus (Silurana) tropicalis
100593533 Nomascus leucogenys
432292 Xenopus laevis
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