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anti-Breast Cancer Susceptibility Protein 2 (BRCA2) Antibodies

tumor suppression gene; involved in repair of double-strand DNA breaks (DSBs) by homologous recombination.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse BRCA2 BRCA2 12190 P97929
Anti-Rat BRCA2 BRCA2 360254  
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More Antibodies against Breast Cancer Susceptibility Protein 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Breast Cancer Susceptibility Protein 2 (BRCA2) interaction partners

  1. persistent meiotic DNA double-strand breaks might correspond to crossovers, which are mobilized to the nuclear envelope for their repair; Brca2-Pds5 complexes may be key mediators of this process.

  2. A mutation in Cyp6d2, a cytochrome P450 (show PHM Antibodies) gene, when combined with a brca2 mutation, resulted in synergistic hypersensitivity to camptothecin.

  3. DNA repair by homologous recombination is dramatically decreased in CG30169 (brca2 homolog) mutants.

Mouse (Murine) Breast Cancer Susceptibility Protein 2 (BRCA2) interaction partners

  1. Merit40 (show BABAM1 Antibodies) mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 (show FANCD2 Antibodies) mutation.

  2. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  3. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  4. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (show PARP1 Antibodies) inhibition.

  5. BRCA2-mediated sequestration of nuclear RAD51 (show RAD51 Antibodies) serves to prevent inappropriate DNA interactions.

  6. BRCA2 directly represses the expression of IFN-related genes

  7. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  8. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

  9. Results suggest that cellular levels of Brca2 and Rad51 (show RAD51 Antibodies) are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Antibodies), which permits cell growth

  10. BRCA2 accumulates DNA damage, which triggers checkpoint signalling and ARF (show CDKN2A Antibodies) activation

Breast Cancer Susceptibility Protein 2 (BRCA2) Antigen Profile

Protein Summary

tumor suppression gene\; involved in repair of double-strand DNA breaks (DSBs) by homologous recombination

Gene names and symbols associated with BRCA2

  • Breast cancer 2, early onset homolog (Brca2) antibody
  • breast cancer 2 (Brca2) antibody
  • breast cancer 2, early onset (Brca2) antibody
  • breast cancer 2, early onset (BRCA2) antibody
  • 30169 antibody
  • AI256696 antibody
  • AW045498 antibody
  • BcDNA:SD25109 antibody
  • brca2 antibody
  • CG13583 antibody
  • CG13584 antibody
  • CG30169 antibody
  • dmbrca2 antibody
  • Dmel\\CG30169 antibody
  • Fancd1 antibody
  • RAB163 antibody

Protein level used designations for BRCA2

breast cancer 2, early onset homolog , CG30169-PA , Brca2-PA , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

GENE ID SPECIES
37916 Drosophila melanogaster
12190 Mus musculus
360254 Rattus norvegicus
493878 Felis catus
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