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BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Additionally we are shipping BIN1 Proteins (15) and BIN1 Kits (7) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal BIN1 Primary Antibody for WB - ABIN395214
Biffi, Anderson, Desikan, Sabuncu, Cortellini, Schmansky, Salat, Rosand,: Genetic variation and neuroimaging measures in Alzheimer disease. in Archives of neurology 2010
Show all 5 references for ABIN395214
Chicken Monoclonal BIN1 Primary Antibody for IHC (fro), IHC (p) - ABIN1105531
Sakamuro, Elliott, Wechsler-Reya, Prendergast: BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. in Nature genetics 1996
Show all 2 references for ABIN1105531
Mouse (Murine) Monoclonal BIN1 Primary Antibody for IP, ELISA - ABIN1043738
Wechsler-Reya, Elliott, Prendergast: A role for the putative tumor suppressor Bin1 in muscle cell differentiation. in Molecular and cellular biology 1998
Human Polyclonal BIN1 Primary Antibody for EIA, WB - ABIN375175
Ghaneie, Zemba-Palko, Itoh, Itoh, Sakamuro, Nakamura, Soler, Prendergast: Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. in Cancer biology & therapy 2007
Mouse (Murine) Monoclonal BIN1 Primary Antibody for FACS, IP - ABIN1043736
Sinha-Datta, Datta, Ghorbel, Dodon, Nicot: Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. in The Journal of biological chemistry 2007
Mouse (Murine) Monoclonal BIN1 Primary Antibody for IP, IHC - ABIN1043740
Nicot, Toussaint, Tosch, Kretz, Wallgren-Pettersson, Iwarsson, Kingston, Garnier, Biancalana, Oldfors, Mandel, Laporte: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. in Nature genetics 2007
Human Monoclonal BIN1 Primary Antibody for ELISA, WB - ABIN1043790
Wechsler-Reya, Sakamuro, Zhang, Duhadaway, Prendergast: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. in The Journal of biological chemistry 1998
Alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the age of onset of GBA (show GBA Antibodies)-associated Parkinson.
Data demonstrate that EHBP1L1 links Rab8 (show RAB8A Antibodies) and the Bin1-dynamin (show DNM1 Antibodies) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
In vitro studies in human Caco-2 cells showed that Bin1 antibody altered the expression of tight junction proteins and improved barrier function.
This study demonistrated that BIN1 mutation releated to Centronuclear myopathy.
Results show low expression of Bin1, along with high expression of IDO (show IDO1 Antibodies), are predictor for poor prognosis in esophageal squamous cell cancer and thereby could be used to establish new therapeutic strategies.
The frequencies of BIN1 alleles were similar in both control and Alzheimer patients showing o no association.
The study is the first to confirm the association of the variant rs7561528 adjacent to Bin1 with Sporadic Alzheimer's Disease in a Han Chinese Population.
These findings suggest that an intracellular form CLU (show CLU Antibodies) and BIN1 interaction might impact Tau function in neurons and uncover potential new mechanisms underlying the etiology of Tau pathology in in Alzheimer's disease.
Reduced BIN1 expression is associated with cutaneous T-cell lymphoma.
BIN1 rs744373 polymorphism is significantly associated with late onset Alzheimer disease.
Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.
Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.
Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.
The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (show E2F1 Antibodies) is a mechanism by which serum starvation promotes E2F1 (show E2F1 Antibodies)-induced apoptosis.
BIN1 interacts with MTM1 (show MTM1 Antibodies) in skeletal muscle.
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.
Data have identified that membrane-associated BIN1 not only induces membrane curvature but can direct specific antegrade delivery of microtubule-transported membrane proteins.
BIN1 is transcriptionally activated by E2F1 (show E2F1 Antibodies) and mediates E2F1 (show E2F1 Antibodies)-induced apoptosis in response to DNA damage.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
bridging integrator 1
, myc box-dependent-interacting protein 1-like
, amphiphysin II
, amphiphysin-like protein
, box dependant MYC interacting protein 1
, box-dependent myc-interacting protein 1
, myc box-dependent-interacting protein 1
, SH3 domain-containing protein 9
, amphiphysin 2
, myc box dependent interacting protein 1
, amphiphysin IIamph2