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BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Additionally we are shipping BIN1 Proteins (15) and BIN1 Kits (11) and many more products for this protein.
Showing 10 out of 108 products:
Human Monoclonal BIN1 Primary Antibody for WB - ABIN395214
Biffi, Anderson, Desikan, Sabuncu, Cortellini, Schmansky, Salat, Rosand,: Genetic variation and neuroimaging measures in Alzheimer disease. in Archives of neurology 2010
Show all 5 references for 395214
Chicken Monoclonal BIN1 Primary Antibody for IHC (fro), IHC (p) - ABIN1105531
Sakamuro, Elliott, Wechsler-Reya, Prendergast: BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. in Nature genetics 1996
Show all 2 references for 1105531
Mouse (Murine) Monoclonal BIN1 Primary Antibody for IP, ELISA - ABIN1043738
Wechsler-Reya, Elliott, Prendergast: A role for the putative tumor suppressor Bin1 in muscle cell differentiation. in Molecular and cellular biology 1998
Mouse (Murine) Monoclonal BIN1 Primary Antibody for FACS, IP - ABIN1043736
Sinha-Datta, Datta, Ghorbel, Dodon, Nicot: Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. in The Journal of biological chemistry 2007
Mouse (Murine) Monoclonal BIN1 Primary Antibody for IP, IHC - ABIN1043740
Nicot, Toussaint, Tosch, Kretz, Wallgren-Pettersson, Iwarsson, Kingston, Garnier, Biancalana, Oldfors, Mandel, Laporte: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. in Nature genetics 2007
Human Monoclonal BIN1 Primary Antibody for ELISA, WB - ABIN1043790
Wechsler-Reya, Sakamuro, Zhang, Duhadaway, Prendergast: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. in The Journal of biological chemistry 1998
Human Polyclonal BIN1 Primary Antibody for ELISA, WB - ABIN334360
Ghaneie, Zemba-Palko, Itoh, Itoh, Sakamuro, Nakamura, Soler, Prendergast: Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. in Cancer biology & therapy 2007
the depletion of BIN1 increases cellular BACE1 (show BACE Antibodies) levels through impaired endosomal trafficking and reduces BACE1 (show BACE Antibodies) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE Antibodies) levels and Ab production
BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.
data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.
findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.
analysis of a novel deregulated mechanism in chronic myeloid leukemia (show BCL11A Antibodies) patients, indicating BIN1 and RIN1 (show RIN1 Antibodies) as players in the maintenance of the abnormal RTK signaling in this hematological disease
BIN1 is involved with late onset Alzheimer's disease. [review]
This study supported that BIN1 contributes to the risk of Alzheimer's disease by altering neural degeneration (abnormal tau, brain atrophy and glucose metabolism) but not Abeta (show APP Antibodies) pathology
Alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the age of onset of GBA (show GBA Antibodies)-associated Parkinson.
Data demonstrate that EHBP1L1 links Rab8 (show RAB8A Antibodies) and the Bin1-dynamin (show DNM1 Antibodies) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
In vitro studies in human Caco-2 cells showed that Bin1 antibody altered the expression of tight junction proteins and improved barrier function.
Bin1 and CD2AP (show Cd2ap Antibodies) keep APP (show APP Antibodies) and BACE1 (show BACE Antibodies) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (show APP Antibodies) in neurons increasing the risk for late-onset AD.
Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.
Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.
Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.
The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (show E2F1 Antibodies) is a mechanism by which serum starvation promotes E2F1 (show E2F1 Antibodies)-induced apoptosis.
BIN1 interacts with MTM1 (show MTM1 Antibodies) in skeletal muscle.
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
bridging integrator 1
, myc box-dependent-interacting protein 1-like
, amphiphysin II
, amphiphysin-like protein
, box dependant MYC interacting protein 1
, box-dependent myc-interacting protein 1
, myc box-dependent-interacting protein 1
, SH3 domain-containing protein 9
, amphiphysin 2
, myc box dependent interacting protein 1
, amphiphysin IIamph2