anti-Bridging Integrator 1 (BIN1) Antibodies

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Additionally we are shipping BIN1 Proteins (15) and BIN1 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839
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Top anti-BIN1 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Bin1 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Mouse Pancreas 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot of Mouse Anti-BIN-1 Antibody. Lane 1: LNCap. Lane 2: WM1341D. Lane 3: WM164. Lane 4: WM983A. Lane 5: WM793. Lane 6: WM239A. Lane 7: WM35. Load: 35 µg per lane. Primary antibody: BIN-1 antibody (Exon 12A specific) at 1:400 for overnight at 4°C. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. 25 μL Log in to see 1 to 2 Days
$135.00
Details
Human Goat Un-conjugated ELISA, WB ABIN334360 (0.1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence 100 μg Log in to see 6 to 7 Days
$326.89
Details
Chicken Mouse Un-conjugated IHC (fro), IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Mouse Mouse Un-conjugated FACS, IP, IHC, ELISA, WB Western Blot of Anti-BIN1 Antibody. Lane 1: Keratinocyte derived from Bin1 wild type mice. Lane 2: Keratinocyte derived from Bin1 null mice. Load: 35 µg per lane. Primary antibody: BIN1 monoclonal Antibody. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 1xPBS, 0.4% Tween-20. Other band(s): non-specific 25 μL Log in to see 1 to 2 Days
$135.00
Details
Mouse Mouse Un-conjugated IP, IHC, ELISA, WB Immunohistochemistry of Mouse Anti-BIN1 antibody. Tissue: skeletal muscle from BIN-1 wild type (+/+) and null (-/-) mouse. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: BIN-1 antibody for 1hr at RT. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: BIN1 is nuclear and cytoplasmic. Staining: BIN1 as precipitated brown signal. 25 μL Log in to see 1 to 2 Days
$135.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of BIN-1 expression in Jurkat cells treated with (Lane 1) or without (Lane 2) camptothecin. 100 μg Log in to see 2 to 3 Days
$245.00
Details
Mouse Mouse Un-conjugated IP, ELISA, WB Immunofluorescence Microscopy of Mouse Anti-BIN1 Antibody. Cells: C2C12 cells during growth or differentiation. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: BIN-1 (Exon 10 specific, 99F) monoclonal antibody. Secondary antibody: mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: BIN1 is nuclear and cytoplasmic. Staining: BIN 1 as green fluorescent signal. 25 μL Log in to see 1 to 2 Days
$135.00
Details
Human Mouse Un-conjugated WB BIN1 monoclonal antibody (M01), clone 1H1 Western Blot analysis of BIN1 expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

BIN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BIN1 Antibodies

  1. Human Polyclonal BIN1 Primary Antibody for ICC, IF - ABIN4284657 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

  2. Mouse (Murine) Monoclonal BIN1 Primary Antibody for FACS, IP - ABIN1043735 : Nicot, Toussaint, Tosch, Kretz, Wallgren-Pettersson, Iwarsson, Kingston, Garnier, Biancalana, Oldfors, Mandel, Laporte: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. in Nature genetics 2007 (PubMed)

  3. Mouse (Murine) Monoclonal BIN1 Primary Antibody for FACS, IP - ABIN1043736 : Sinha-Datta, Datta, Ghorbel, Dodon, Nicot: Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. in The Journal of biological chemistry 2007 (PubMed)

  4. Mouse (Murine) Monoclonal BIN1 Primary Antibody for IP, ELISA - ABIN1043737 : Wechsler-Reya, Elliott, Prendergast: A role for the putative tumor suppressor Bin1 in muscle cell differentiation. in Molecular and cellular biology 1998 (PubMed)

  5. Human Monoclonal BIN1 Primary Antibody for ELISA, WB - ABIN1043790 : Wechsler-Reya, Sakamuro, Zhang, Duhadaway, Prendergast: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. in The Journal of biological chemistry 1998 (PubMed)

More Antibodies against BIN1 Interaction Partners

Human Bridging Integrator 1 (BIN1) interaction partners

  1. The results emphasize an additional level of complexity in the regulation of the interaction between BIN1 and Tau dependent on the BIN1 isoforms.

  2. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (show CHMP4A Antibodies) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (show CHMP4A Antibodies) = charged multivesicular body protein 4B (show CHMP4B Antibodies); cBIN1 = cardiac bridging integrator 1)

  3. Low Bin1 expression is associated with esophageal squamous cell carcinoma.

  4. the depletion of BIN1 increases cellular BACE1 (show BACE Antibodies) levels through impaired endosomal trafficking and reduces BACE1 (show BACE Antibodies) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE Antibodies) levels and Ab production

  5. BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.

  6. data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.

  7. findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.

  8. analysis of a novel deregulated mechanism in chronic myeloid leukemia (show BCL11A Antibodies) patients, indicating BIN1 and RIN1 (show RIN1 Antibodies) as players in the maintenance of the abnormal RTK signaling in this hematological disease

  9. BIN1 is involved with late onset Alzheimer's disease. [review]

  10. This study supported that BIN1 contributes to the risk of Alzheimer's disease by altering neural degeneration (abnormal tau, brain atrophy and glucose metabolism) but not Abeta (show APP Antibodies) pathology

Mouse (Murine) Bridging Integrator 1 (BIN1) interaction partners

  1. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (show CHMP4B Antibodies) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (show CHMP4B Antibodies) = charged multivesicular body protein 4B (show CHMP4B Antibodies); cBIN1 = cardiac bridging integrator 1)

  2. Bin1 and CD2AP (show Cd2ap Antibodies) keep APP (show APP Antibodies) and BACE1 (show BACE Antibodies) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (show APP Antibodies) in neurons increasing the risk for late-onset AD.

  3. the depletion of BIN1 increases cellular BACE1 (show BACE Antibodies) levels through impaired endosomal trafficking and reduces BACE1 (show BACE Antibodies) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE Antibodies) levels and Ab production

  4. Data demonstrate that EHBP1L1 links Rab8 (show RAB8A Antibodies) and the Bin1-dynamin (show DNM1 Antibodies) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  5. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  6. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  7. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  8. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (show E2F1 Antibodies) is a mechanism by which serum starvation promotes E2F1 (show E2F1 Antibodies)-induced apoptosis.

  9. BIN1 interacts with MTM1 (show MTM1 Antibodies) in skeletal muscle.

  10. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

BIN1 Antigen Profile

Protein Summary

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Gene names and symbols associated with BIN1

  • bridging integrator 1 (BIN1) antibody
  • bridging integrator 1 (bin1) antibody
  • bridging integrator 1 (Bin1) antibody
  • ALP-1 antibody
  • AMPH2 antibody
  • Amphl antibody
  • BIN1 antibody
  • BRAMP-2 antibody
  • cb57 antibody
  • MGC53185 antibody
  • MGC76187 antibody
  • SH3P9 antibody
  • zgc:86701 antibody

Protein level used designations for BIN1

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPECIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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