Bridging Integrator 1 Proteins (BIN1)

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Additionally we are shipping BIN1 Antibodies (106) and BIN1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839
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Top BIN1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,688.67
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,035.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 15 to 18 Days
$688.00
Details

BIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced BIN1 Proteins

  1. Human BIN1 Protein expressed in Escherichia coli (E. coli) - ABIN2004237 : Butler, David, Ochoa, Freyberg, Daniell, Grabs, Cremona, De Camilli et al.: Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in ... in The Journal of cell biology 1997 (PubMed)
    Show all 3 references for 2004237

  2. Human BIN1 Protein expressed in Escherichia coli (E. coli) - ABIN667182 : Nanda, Herion, Liang: The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity. in Gastroenterology 2006 (PubMed)
    Show all 2 references for 667182

More Proteins for Bridging Integrator 1 (BIN1) Interaction Partners

Human Bridging Integrator 1 (BIN1) interaction partners

  1. the depletion of BIN1 increases cellular BACE1 (show BACE Proteins) levels through impaired endosomal trafficking and reduces BACE1 (show BACE Proteins) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE Proteins) levels and Ab production

  2. BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.

  3. data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.

  4. findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.

  5. analysis of a novel deregulated mechanism in chronic myeloid leukemia (show BCL11A Proteins) patients, indicating BIN1 and RIN1 (show RIN1 Proteins) as players in the maintenance of the abnormal RTK signaling in this hematological disease

  6. BIN1 is involved with late onset Alzheimer's disease. [review]

  7. This study supported that BIN1 contributes to the risk of Alzheimer's disease by altering neural degeneration (abnormal tau, brain atrophy and glucose metabolism) but not Abeta (show APP Proteins) pathology

  8. Alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the age of onset of GBA (show GBA Proteins)-associated Parkinson.

  9. Data demonstrate that EHBP1L1 links Rab8 (show RAB8A Proteins) and the Bin1-dynamin (show DNM1 Proteins) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  10. In vitro studies in human Caco-2 cells showed that Bin1 antibody altered the expression of tight junction proteins and improved barrier function.

Mouse (Murine) Bridging Integrator 1 (BIN1) interaction partners

  1. Bin1 and CD2AP (show Cd2ap Proteins) keep APP (show APP Proteins) and BACE1 (show BACE Proteins) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (show APP Proteins) in neurons increasing the risk for late-onset AD.

  2. the depletion of BIN1 increases cellular BACE1 (show BACE Proteins) levels through impaired endosomal trafficking and reduces BACE1 (show BACE Proteins) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE Proteins) levels and Ab production

  3. Data demonstrate that EHBP1L1 links Rab8 (show RAB8A Proteins) and the Bin1-dynamin (show DNM1 Proteins) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  4. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  5. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  6. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  7. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (show E2F1 Proteins) is a mechanism by which serum starvation promotes E2F1 (show E2F1 Proteins)-induced apoptosis.

  8. BIN1 interacts with MTM1 (show MTM1 Proteins) in skeletal muscle.

  9. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

  10. Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.

BIN1 Protein Profile

Protein Summary

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Gene names and symbols associated with Bridging Integrator 1 Proteins (BIN1)

  • bridging integrator 1 (BIN1)
  • bridging integrator 1 (bin1)
  • bridging integrator 1 (Bin1)
  • ALP-1 protein
  • AMPH2 protein
  • Amphl protein
  • BIN1 protein
  • BRAMP-2 protein
  • cb57 protein
  • MGC53185 protein
  • MGC76187 protein
  • SH3P9 protein
  • zgc:86701 protein

Protein level used designations for Bridging Integrator 1 Proteins (BIN1)

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPECIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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