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Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Additionally we are shipping and many more products for this protein.
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Human Polyclonal BAZ2A Primary Antibody for ELISA, WB - ABIN1451082
Jones, Hamana, Nezu, Shimane: A novel family of bromodomain genes. in Genomics 2000
Show all 2 references for ABIN1451082
Data show that SUMOylated BANP (show BANP Antibodies), E5R, and Nac1 (show NACC1 Antibodies) (BEN (show GTF2IRD1 Antibodies)) domain 3 (BEND3) stabilizes NoRC component TTF-1 (show NKX2-1 Antibodies)-interacting protein 5 (show CAPS Antibodies) (Tip5)via association with ubiquitin specific protease 21 (USP21 (show USP21 Antibodies)) debiquitinase
Crystal structures of PHD (show PDC Antibodies) zinc finger and bromodomains from human TIP5 and BAZ2B (show BAZ2B Antibodies) in free form and bound to H3 and/or H4 histones.
The study showed that the NMR structure of the TAM (show CCNA1 Antibodies) domain of TIP5 resembles the fold of the MBD (show DPEP1 Antibodies) domain, found in methyl-CpG binding proteins.
BAZ2A is overexpressed in prostate cancer, maintains its cell growth, regulates protein-coding genes, and interacts with EZH2 (show EZH2 Antibodies) to silence genes repressed in metastasis. Its overexpression is associated with a CpG island methylator phenotype.
High BAZ2A expression is associated with pancreatic cancer.
Data show that MOF (show KAT8 Antibodies) acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (show SIRT1 Antibodies) (removes the acetyl group from K633.
NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
Tip5 not only mediates the establishment of rDNA silencing but also the formation of perinucleolar heterochromatin that contains centric and pericentric repeats.
Overexpression of TIP5, the large subunit of NoRC, mediates deacetylation of nucleosomes near the rDNA promoter. TIP5 associates with HDAC1 (show HDAC1 Antibodies) in vivo & in vitro. Deletion of the C-terminal PHD (show PDC Antibodies) finger & bromodomain abolishes the interaction of TIP5 & HDAC1 (show HDAC1 Antibodies).
The PHD (show PDC Antibodies) finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
Mutations that disrupt the stem-loop structure impair binding of TIP5, the large subunit of NoRC, to pRNA and abolish targeting of NoRC to nucleoli.
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter\; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity).
bromodomain adjacent to zinc finger domain protein 2A
, bromodomain adjacent to zinc finger domain, 2A
, bromodomain adjacent to zinc finger domain protein 2A-like
, TTF-I interacting peptide 5
, TTF-I-interacting protein 5
, transcription termination factor I-interacting protein 5
, Transcription termination factor I-interacting protein 5
, putative chromatin remodelling factor BAZ2A