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BRD2 encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. Additionally we are shipping BRD2 Antibodies (65) and BRD2 Proteins (10) and many more products for this protein.
Showing 8 out of 9 products:
LRP1B (show LRP1B ELISA Kits), BRD2 and CACNA1D (show CACNA1D ELISA Kits) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (show CHUK ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 and BRD4 (show BRD4 ELISA Kits) in maintaining oncogenic IKK (show CHUK ELISA Kits) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 and Brd4 (show BRD4 ELISA Kits), may play a key role in the regulation of Nrf2 (show GABPA ELISA Kits)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
The SNP alleles in BRD2, Cx-36 (show GJD2 ELISA Kits), and ME2 (show CELSR1 ELISA Kits) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'
BRD2, BRD3 (show BRD3 ELISA Kits), and BRD4 (show BRD4 ELISA Kits) interact with gammaretroviral INs (show INS ELISA Kits) and serve as cofactors for murine leukemia virus integration.
our results identify BRD2 as a new Tat (show TAT ELISA Kits)-independent suppressor of HIV transcription in latently infected cells and underscore the therapeutic potential of BET inhibitors in the reversal of HIV latency.
Brd2 and Brd4 (show BRD4 ELISA Kits) proteins mediatE the responses of LFs after growth factor stimulation and drivE the induction of lung fibrosis in mice in response to bleomycin challenge.
BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 (show SERPINE1 ELISA Kits) and via the regulation of epigenetic reader BET protein
DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes.
Brd2 inhibits adipogenesis via the ERK1/2 (show MAPK1/3 ELISA Kits) signaling pathway in 3T3-L1 adipocytes.
We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes
Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter.
Identification of motif B of Brd2 as a dimerization domain involved in association to mitotic chromosomes and proper recognition of acetylated chromatin.
These findings suggest that Brd2 is required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 (show E2F1 ELISA Kits) pathway during mouse CNS development.
Studies showed that although Brd2 mRNA is expressed in both the hippocampus and cerebellum, Brd2 protein only can be detected in the cerebellar Purkinje cells and not in hippocampal cells.
Compared to the Brd2+/+ littermates, Brd2+/- males have a decreased clonic, and females a decreased tonic-clonic, seizure threshold.
brd2a on chromosome 19 exhibits both maternal and zygotic contributions to early development and patterning, analogous to the brd2 ortholog in Drosophila.
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, collagen type XI alpha 2
, glutamate-cysteine ligase catalytic subunit
, ring finger protein 3