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Bromodomain Containing 2 Proteins (BRD2)

BRD2 encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. Additionally we are shipping BRD2 Antibodies (65) and BRD2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRD2 6046 P25440
BRD2 14312 Q7JJ13
BRD2 294276 Q6MGA9
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Top BRD2 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$253.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant BRD2 (344-455) activity using AlphaScreen. BRD2 (344-455) titration and inhibition were assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. An IC50 dose response assessment of reference compounds JQ1, I-BET151, Bromosporine and PFI-1 is also shown. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRD2 (344-455) protein gel. BRD2 (344-455) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,343.17
Details

BRD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Bromodomain Containing 2 (BRD2) Interaction Partners

Human Bromodomain Containing 2 (BRD2) interaction partners

  1. LRP1B (show LRP1B Proteins), BRD2 and CACNA1D (show CACNA1D Proteins) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.

  2. This study implicates BET Brds as important regulators of IkappaB kinase (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.

  3. An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 and BRD4 (show BRD4 Proteins) in maintaining oncogenic IKK (show CHUK Proteins) activity in activated B-cell-like diffuse large B-cell lymphoma.

  4. BET proteins, particularly Brd2 and Brd4 (show BRD4 Proteins), may play a key role in the regulation of Nrf2 (show GABPA Proteins)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.

  5. The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.

  6. A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

  7. The SNP alleles in BRD2, Cx-36 (show GJD2 Proteins), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'

  8. BRD2, BRD3 (show BRD3 Proteins), and BRD4 (show BRD4 Proteins) interact with gammaretroviral INs (show INS Proteins) and serve as cofactors for murine leukemia virus integration.

  9. our results identify BRD2 as a new Tat (show TAT Proteins)-independent suppressor of HIV transcription in latently infected cells and underscore the therapeutic potential of BET inhibitors in the reversal of HIV latency.

  10. Brd2 and Brd4 (show BRD4 Proteins) proteins mediatE the responses of LFs after growth factor stimulation and drivE the induction of lung fibrosis in mice in response to bleomycin challenge.

Mouse (Murine) Bromodomain Containing 2 (BRD2) interaction partners

  1. BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 (show SERPINE1 Proteins) and via the regulation of epigenetic reader BET protein

  2. DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes.

  3. Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.

  4. A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

  5. We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes

  6. Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter.

  7. Identification of motif B of Brd2 as a dimerization domain involved in association to mitotic chromosomes and proper recognition of acetylated chromatin.

  8. These findings suggest that Brd2 is required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 (show E2F1 Proteins) pathway during mouse CNS development.

  9. Studies showed that although Brd2 mRNA is expressed in both the hippocampus and cerebellum, Brd2 protein only can be detected in the cerebellar Purkinje cells and not in hippocampal cells.

  10. Compared to the Brd2+/+ littermates, Brd2+/- males have a decreased clonic, and females a decreased tonic-clonic, seizure threshold.

Zebrafish Bromodomain Containing 2 (BRD2) interaction partners

  1. brd2a on chromosome 19 exhibits both maternal and zygotic contributions to early development and patterning, analogous to the brd2 ortholog in Drosophila.

BRD2 Protein Profile

Protein Summary

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.

Gene names and symbols associated with BRD2

  • Ring3 protein (CHLREDRAFT_190116)
  • Ring3 protein (CHLREDRAFT_150233)
  • Ring3 protein (CHLREDRAFT_182576)
  • Ring3 protein (CHLREDRAFT_188250)
  • bromodomain containing 2 (BRD2)
  • bromodomain containing 2 (Brd2)
  • bromodomain containing 2 (brd2)
  • bromodomain-containing 2a (brd2a)
  • AW228947 protein
  • brd2 protein
  • brd2-a protein
  • D6S113E protein
  • D17H6S113E protein
  • fe47f02 protein
  • fi85h05 protein
  • Frg-1 protein
  • fsh protein
  • Fsrg-1 protein
  • fsrg1 protein
  • mKIAA4005 protein
  • nat protein
  • ring3 protein
  • rnf3 protein
  • wu:fe47f02 protein
  • wu:fi85h05 protein

Protein level used designations for BRD2

Ring3 protein , O27.1.1 , bromodomain-containing 2 , bromodomain-containing protein 2 , female sterile homeotic-related gene 1 , really interesting new gene 3 protein , collagen type XI alpha 2 , glutamate-cysteine ligase catalytic subunit , ring finger protein 3

GENE ID SPECIES
5715712 Chlamydomonas reinhardtii
5721686 Chlamydomonas reinhardtii
5724100 Chlamydomonas reinhardtii
5728991 Chlamydomonas reinhardtii
6046 Homo sapiens
417049 Gallus gallus
474868 Canis lupus familiaris
100141307 Sus scrofa
505358 Bos taurus
14312 Mus musculus
294276 Rattus norvegicus
394399 Xenopus laevis
30445 Danio rerio
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