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The protein encoded by BRWD3 contains a bromodomain and several WD repeats. Additionally we are shipping BRWD3 Antibodies (21) and and many more products for this protein.
Intellectual disability-associated BRWD3 regulates gene expression through inhibition of HIRA (show HIRA ELISA Kits)/YEM-mediated chromatin deposition of histone H3.3.
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1 (show DDB1 ELISA Kits))- and CULLIN (show CUL5 ELISA Kits) (CUL)4-associated factor in a Cullin4-RING Finger (show PCGF1 ELISA Kits) E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1 (show RIT1 ELISA Kits)-DDB1 (show DDB1 ELISA Kits)-BRWD3, inducing ubiquitylation of dCRY
In the developing retina, ramshackle (ram) mutant cells have morphological defects including disrupted apical junctions, disorganized actin (show ACTB ELISA Kits) cytoskeletons and mislocalized nuclei.
A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly.
BRWD3 is therefore a new gene implicated in the etiology of XLMR (show DLG3 ELISA Kits) associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation.
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene cause mental retardation X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia.
, lethal (3) 05842
, BRWD3 protein
, bromo domain-containing protein disrupted in leukemia
, bromodomain and WD repeat-containing protein 3
, novel WD repeat domain protein