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Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) ELISA Kits

BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Antibodies (140) and BUB1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human BUB1 BUB1 699 O43683
Anti-Rat BUB1 BUB1 296137  
Anti-Mouse BUB1 BUB1 12235 O08901
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More ELISA Kits for BUB1 Interaction Partners

Human Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Bub1 may be associated with cancer stem cell potential.

  2. Both Bub1 and BubR1 (show BUB1B ELISA Kits) bind stably to Bub3 (show BUB3 ELISA Kits) that is required for kinetochore localization of the proteins

  3. Bub1-Plk1 (show PLK1 ELISA Kits)-mediated phosphorylation of Cdc20 (show CDC20 ELISA Kits) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (show BUB3 ELISA Kits) complex formation.

  4. Data show that mitotic checkpoint (show BUB3 ELISA Kits) kinase (show ATR ELISA Kits) Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.

  5. human BUB1 does not associate stably with the MAD2 (show MAD2L1 ELISA Kits) activator MAD1 (show MXD1 ELISA Kits) (also known as MAD1L1 (show MAD1L1 ELISA Kits)) and, although required for accelerating the loading of MAD1 (show MXD1 ELISA Kits) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (show MXD1 ELISA Kits) there

  6. MAD2L1 (show MAD2L1 ELISA Kits) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

  7. Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.

  8. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B ELISA Kits) recruitment and localizes antagonistic checkpoint activities.

  9. BUB1B (show BUB1B ELISA Kits) expression was highly correlated to CDC20 (show CDC20 ELISA Kits) and CCNB1 (show CCNB1 ELISA Kits) expression in multiple myeloma cells, leading to increased cell proliferation.Bub1 expression promotes cell proliferation and leads to poor survival in multiple myeloma patients

  10. BubR1 (show BUB1B ELISA Kits) is a component of the Mitotic checkpoint (show BUB3 ELISA Kits) complex and was reported to be overexpressed in Breast cancer. BubR1 (show BUB1B ELISA Kits) overexpression was correlated with poor survival in early stage Breast cancer patients.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B ELISA Kits) recruitment and localizes antagonistic checkpoint activities.

  2. It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.

  3. Results establish that Bub1 has oncogenic properties and suggest that Aurora B (show AURKC ELISA Kits) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.

  4. It seems that Sgo1 (show SGOL1 ELISA Kits) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  5. mutations of Bub1 and BubR1 (show BUB1B ELISA Kits) found in Brca2 (show BRCA2 ELISA Kits)- mutant mice indeed are responsible for the chromosome instability in Brca2 (show BRCA2 ELISA Kits)-mutated tumors

  6. Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.

  7. Bub1 is important for mediating cell death when chromosomes missegregate.

  8. Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.

  9. Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.

  10. Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.

BUB1 Antigen Profile

Antigen Summary

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.

Gene names and symbols associated with BUB1

  • budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1) antibody
  • BUB1 mitotic checkpoint serine/threonine kinase (bub1) antibody
  • BUB1 mitotic checkpoint serine/threonine kinase (BUB1) antibody
  • BUB1 mitotic checkpoint serine/threonine kinase (Bub1) antibody
  • budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Bub1) antibody
  • AL022991 antibody
  • Bub1a antibody
  • BUB1L antibody
  • C80208 antibody
  • D2Xrf87 antibody
  • hBUB1 antibody
  • xbub1 antibody

Protein level used designations for BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog , mitotic checkpoint serine/threonine-protein kinase BUB1 , budding uninhibited by benzimidazoles 1 , budding uninhibited by benzimidazoles 1 homolog , mitotic spindle checkpoint kinase , putative serine/threonine-protein kinase , mBUB1

GENE ID SPECIES
100064049 Equus caballus
459484 Pan troglodytes
780291 Xenopus (Silurana) tropicalis
699 Homo sapiens
296137 Rattus norvegicus
12235 Mus musculus
100682599 Canis lupus familiaris
514777 Bos taurus
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