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BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Antibodies (142) and many more products for this protein.
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Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.
Study shows that BUB1beta (show BUB1B Proteins) and PDZ binding kinase (show PBK Proteins) are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Bub1 may be associated with cancer stem cell potential.
Both Bub1 and BubR1 (show BUB1B Proteins) bind stably to Bub3 (show BUB3 Proteins) that is required for kinetochore localization of the proteins
Bub1-Plk1-mediated phosphorylation of Cdc20 (show CDC20 Proteins) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (show BUB3 Proteins) complex formation.
Data show that mitotic checkpoint (show BUB3 Proteins) kinase Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.
human BUB1 does not associate stably with the MAD2 (show MAD2L1 Proteins) activator MAD1 (show MXD1 Proteins) (also known as MAD1L1 (show MAD1L1 Proteins)) and, although required for accelerating the loading of MAD1 (show MXD1 Proteins) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (show MXD1 Proteins) there
MAD2L1 (show MAD2L1 Proteins) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.
Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B Proteins) recruitment and localizes antagonistic checkpoint activities.
It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.
Results establish that Bub1 has oncogenic properties and suggest that Aurora B (show AURKC Proteins) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.
It seems that Sgo1 (show SGOL1 Proteins) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
mutations of Bub1 and BubR1 (show BUB1B Proteins) found in Brca2 (show BRCA2 Proteins)- mutant mice indeed are responsible for the chromosome instability in Brca2 (show BRCA2 Proteins)-mutated tumors
Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.
Bub1 is important for mediating cell death when chromosomes missegregate.
Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.
Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog
, mitotic checkpoint serine/threonine-protein kinase BUB1
, budding uninhibited by benzimidazoles 1
, budding uninhibited by benzimidazoles 1 homolog
, mitotic spindle checkpoint kinase
, putative serine/threonine-protein kinase