You are viewing an incomplete version of our website. Please click to reload the website as full version.

Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) Proteins (BUB1)

BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Antibodies (140) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BUB1 699 O43683
Rat BUB1 BUB1 296137  
BUB1 12235 O08901
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top BUB1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BUB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) Interaction Partners

Human Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Bub1 may be associated with cancer stem cell potential.

  2. Both Bub1 and BubR1 (show BUB1B Proteins) bind stably to Bub3 (show BUB3 Proteins) that is required for kinetochore localization of the proteins

  3. Bub1-Plk1-mediated phosphorylation of Cdc20 (show CDC20 Proteins) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (show BUB3 Proteins) complex formation.

  4. Data show that mitotic checkpoint (show BUB3 Proteins) kinase Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.

  5. human BUB1 does not associate stably with the MAD2 (show MAD2L1 Proteins) activator MAD1 (show MXD1 Proteins) (also known as MAD1L1 (show MAD1L1 Proteins)) and, although required for accelerating the loading of MAD1 (show MXD1 Proteins) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (show MXD1 Proteins) there

  6. MAD2L1 (show MAD2L1 Proteins) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

  7. Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.

  8. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B Proteins) recruitment and localizes antagonistic checkpoint activities.

  9. BUB1B (show BUB1B Proteins) expression was highly correlated to CDC20 (show CDC20 Proteins) and CCNB1 (show CCNB1 Proteins) expression in multiple myeloma cells, leading to increased cell proliferation.Bub1 expression promotes cell proliferation and leads to poor survival in multiple myeloma patients

  10. BubR1 (show BUB1B Proteins) is a component of the Mitotic checkpoint (show BUB3 Proteins) complex and was reported to be overexpressed in Breast cancer. BubR1 (show BUB1B Proteins) overexpression was correlated with poor survival in early stage Breast cancer patients.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) interaction partners

  1. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B Proteins) recruitment and localizes antagonistic checkpoint activities.

  2. It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.

  3. Results establish that Bub1 has oncogenic properties and suggest that Aurora B (show AURKC Proteins) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.

  4. It seems that Sgo1 (show SGOL1 Proteins) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  5. mutations of Bub1 and BubR1 (show BUB1B Proteins) found in Brca2 (show BRCA2 Proteins)- mutant mice indeed are responsible for the chromosome instability in Brca2 (show BRCA2 Proteins)-mutated tumors

  6. Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.

  7. Bub1 is important for mediating cell death when chromosomes missegregate.

  8. Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.

  9. Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.

  10. Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.

BUB1 Protein Profile

Protein Summary

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.

Gene names and symbols associated with BUB1

  • budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1)
  • BUB1 mitotic checkpoint serine/threonine kinase (bub1)
  • BUB1 mitotic checkpoint serine/threonine kinase (BUB1)
  • BUB1 mitotic checkpoint serine/threonine kinase (Bub1)
  • budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Bub1)
  • AL022991 protein
  • Bub1a protein
  • BUB1L protein
  • C80208 protein
  • D2Xrf87 protein
  • hBUB1 protein
  • xbub1 protein

Protein level used designations for BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog , mitotic checkpoint serine/threonine-protein kinase BUB1 , budding uninhibited by benzimidazoles 1 , budding uninhibited by benzimidazoles 1 homolog , mitotic spindle checkpoint kinase , putative serine/threonine-protein kinase , mBUB1

GENE ID SPECIES
100064049 Equus caballus
459484 Pan troglodytes
780291 Xenopus (Silurana) tropicalis
699 Homo sapiens
296137 Rattus norvegicus
12235 Mus musculus
100682599 Canis lupus familiaris
514777 Bos taurus
Selected quality suppliers for BUB1 Proteins (BUB1)
Did you look for something else?