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BUB1 encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1 Proteins (6) and many more products for this protein.
Showing 10 out of 139 products:
Human Polyclonal BUB1 Primary Antibody for EIA, IHC (p) - ABIN360514
Shichiri, Yoshinaga, Hisatomi, Sugihara, Hirata: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. in Cancer research 2002
Show all 5 references for ABIN360514
Mouse (Murine) Monoclonal BUB1 Primary Antibody for ICC, FACS - ABIN108553
Liu, Hittle, Jablonski, Campbell, Yoda, Yen: Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. in Nature cell biology 2003
Show all 4 references for ABIN108553
Human Monoclonal BUB1 Primary Antibody for IF, IP - ABIN181741
Vanoosthuyse, Hardwick: Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis. in Trends in cell biology 2005
Show all 3 references for ABIN181741
Human Polyclonal BUB1 Primary Antibody for FACS, WB - ABIN651630
Gambe, Matsunaga, Takata, Ono-Maniwa, Baba, Uchiyama, Fukui: A nucleolar protein RRS1 contributes to chromosome congression. in FEBS letters 2009
Show all 2 references for ABIN651630
Human Polyclonal BUB1 Primary Antibody for IHC (p), WB - ABIN392626
Cayrol, Cougoule, Wright: The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1. in Biochemical and biophysical research communications 2002
Show all 2 references for ABIN392626
Human Polyclonal BUB1 Primary Antibody for ELISA, WB - ABIN1452063
Cahill, da Costa, Carson-Walter, Kinzler, Vogelstein, Lengauer: Characterization of MAD2B and other mitotic spindle checkpoint genes. in Genomics 1999
Human Polyclonal BUB1 Primary Antibody for IHC, ELISA - ABIN1533511
Cahill, Lengauer, Yu, Riggins, Willson, Markowitz, Kinzler, Vogelstein: Mutations of mitotic checkpoint genes in human cancers. in Nature 1998
Human Polyclonal BUB1 Primary Antibody for EIA, IF - ABIN499509
Pangilinan, Li, Weaver, Lewis, Dang, Spencer: Mammalian BUB1 protein kinases: map positions and in vivo expression. in Genomics 1998
Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.
Study shows that BUB1beta (show BUB1B Antibodies) and PDZ binding kinase (show PBK Antibodies) are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Bub1 may be associated with cancer stem cell potential.
Both Bub1 and BubR1 (show BUB1B Antibodies) bind stably to Bub3 (show BUB3 Antibodies) that is required for kinetochore localization of the proteins
Bub1-Plk1 (show PLK1 Antibodies)-mediated phosphorylation of Cdc20 (show CDC20 Antibodies) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (show BUB3 Antibodies) complex formation.
Data show that mitotic checkpoint (show BUB3 Antibodies) kinase (show ATR Antibodies) Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.
human BUB1 does not associate stably with the MAD2 (show MAD2L1 Antibodies) activator MAD1 (show MXD1 Antibodies) (also known as MAD1L1 (show MAD1L1 Antibodies)) and, although required for accelerating the loading of MAD1 (show MXD1 Antibodies) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (show MXD1 Antibodies) there
MAD2L1 (show MAD2L1 Antibodies) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.
Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (show BUB1B Antibodies) recruitment and localizes antagonistic checkpoint activities.
It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.
Results establish that Bub1 has oncogenic properties and suggest that Aurora B (show AURKC Antibodies) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.
It seems that Sgo1 (show SGOL1 Antibodies) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
mutations of Bub1 and BubR1 (show BUB1B Antibodies) found in Brca2 (show BRCA2 Antibodies)- mutant mice indeed are responsible for the chromosome instability in Brca2 (show BRCA2 Antibodies)-mutated tumors
Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.
Bub1 is important for mediating cell death when chromosomes missegregate.
Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.
Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog
, mitotic checkpoint serine/threonine-protein kinase BUB1
, budding uninhibited by benzimidazoles 1
, budding uninhibited by benzimidazoles 1 homolog
, mitotic spindle checkpoint kinase
, putative serine/threonine-protein kinase