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BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Antibodies (180) and BUB1B Kits (1) and many more products for this protein.
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Together, our findings demonstrate that Bub1 (show BUB1 Proteins) acts at multiple points to assure the correct kinetochore formation.
The Bub3 (show BUB3 Proteins)-BubR1 complex on broken DNA inhibits the APC (show APC Proteins)/C locally via the sequestration of Cdc20 (show CDC20 Proteins).
a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (show CDC20 Proteins) kinetochore recruitment and sustained SAC (show ADCY10 Proteins) function.
Data show that the Mad2 (show MAD2L1 Proteins) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (show CDC20 Proteins) to kinetochores in Drosophila requires BubR1 but not Mad2 (show MAD2L1 Proteins).
Reduced BubR1 or Polo function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
BubR1's role in mitosis is discussed.
BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis
BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (show CENPE Proteins).
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (show CDC20 Proteins)-APC (show APC Proteins) function, preventing the metaphase-to-anaphase transition.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (show MYO5A Proteins) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (show PPP2R4 Proteins) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (show PPP2R4 Proteins) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (show MAD2L1 Proteins) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (show BUB3 Proteins) complex depends on the specific recognition between BubR1 and Bub3 (show BUB3 Proteins), for which the BubR1 Gle2 (show RAE1 Proteins) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (show BUB3 Proteins) by BUB1 (show BUB1 Proteins) is dispensable for SAC (show ADCY10 Proteins) activation
Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.
BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9 (show CA9 Proteins)-22 and Cal (show FBLIM1 Proteins)-27 cells.
BubR1 contributes to preventing premature aging. [review]
EZH2 (show EZH2 Proteins) directly interacted with and stabilized BubR1, an effect driving EZH2 (show EZH2 Proteins) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Proteins), and Ercc1 (show ERCC1 Proteins)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (show ERCC1 Proteins)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Proteins) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (show SIRT2 Proteins) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (show CREBBP Proteins).
BubR1 insufficiency elicits an aging response that is counteracted by p53 (show TP53 Proteins) and involves single or multiple p53 (show TP53 Proteins) targets, depending on the tissue type.
BubR1 acetylation is essential for embryonic development.
these data demonstrate that the BUBR1 GTTA mutation compromises longevity and healthspan, raising the interesting possibility that mono-allelic changes in BUBR1 might contribute to differences in aging rates in the general population.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like
, bub related one
, MAD3/BUB1-related protein kinase
, mitotic checkpoint kinase MAD3L
, budding uninhibited by benzimidazoles 1 homolog, beta