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anti-C-Type Lectin Domain Family 1, Member B (CLEC1B) Antibodies

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activa. Additionally we are shipping C-Type Lectin Domain Family 1, Member B Proteins (10) and C-Type Lectin Domain Family 1, Member B Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC1B 500336  
CLEC1B 51266 Q9P126
CLEC1B 56760 Q9JL99
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Top anti-C-Type Lectin Domain Family 1, Member B Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated IP, ELISA, WB Detection limit for recombinant GST tagged CLEC1B is 1 ng/ml as a capture antibody. Immunoprecipitation of CLEC1B transfected lysate using anti-CLEC1B monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with CLEC1B MaxPab rabbit polyclonal antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rat PE ICFC 100 μg Log in to see 10 to 12 Days
$298.95
Details
Human Goat Un-conjugated ELISA, WB ABIN263214 (1µg/ml) staining of human kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CLEC2/CLEC1B Polyclonal Antibody, Unconjugated (ABIN741810) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Mouse Rat Un-conjugated FACS, IF 100 μg Log in to see 10 to 12 Days
$217.41
Details
Mouse Rat PE FACS 100 Tests Log in to see 3 to 4 Days
$427.06
Details
Human Mouse APC FACS   100 Tests Log in to see 8 to 10 Days
$969.83
Details

CLEC1B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-C-Type Lectin Domain Family 1, Member B Antibodies

  1. Mouse (Murine) Monoclonal CLEC1B Primary Antibody for ICFC - ABIN2662694 : Acton, Astarita, Malhotra, Lukacs-Kornek, Franz, Hess, Jakus, Kuligowski, Fletcher, Elpek, Bellemare-Pelletier, Sceats, Reynoso, Gonzalez, Graham, Chang, Peters, Woodruff, Kim, Swat, Morita, Kuchroo et al.: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. ... in Immunity 2012 (PubMed)
    Show all 6 references for ABIN2662694

  2. Mouse (Murine) Monoclonal CLEC1B Primary Antibody for FACS, IF - ABIN2664892 : Finney, Schweighoffer, Navarro-Núñez, Bénézech, Barone, Hughes, Langan, Lowe, Pollitt, Mourao-Sa, Sheardown, Nash, Smithers, Reis e Sousa, Tybulewicz, Watson: CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. in Blood 2012 (PubMed)
    Show all 6 references for ABIN2664892

  3. Mouse (Murine) Monoclonal CLEC1B Primary Antibody for FACS - ABIN2473005 : de Lacey, McCabe, Constant, Welch, Spinks, McNally: Testing a policy for skull radiography (and admission) following mild head injury. in The British journal of radiology 1990 (PubMed)
    Show all 3 references for ABIN2473005

  4. Human Polyclonal CLEC1B Primary Antibody for EIA, WB - ABIN374981 : Suzuki-Inoue, Kato, Inoue, Kaneko, Mishima, Yatomi, Yamazaki, Narimatsu, Ozaki: Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. in The Journal of biological chemistry 2007 (PubMed)

  5. Human Monoclonal CLEC1B Primary Antibody for IP, ELISA - ABIN526588 : Manne, Badolia, Dangelmaier, Kunapuli: C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. in Biochemical pharmacology 2015 (PubMed)

More Antibodies against C-Type Lectin Domain Family 1, Member B Interaction Partners

Human C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.

  2. Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation (show CD36 Antibodies) of C (show GP6 Antibodies)D36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2).

  3. PI3K (show PIK3CA Antibodies) and Tec (show NR4A3 Antibodies) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Antibodies) phosphorylation downstream of the CLEC-2 receptor

  4. fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway

  5. Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade

  6. A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation.

  7. The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2.

  8. Shedding of CLEC-2 from the cell surface may reflect increased expression of this membrane protein and serve as a marker of disease activity.

  9. Here, the bidirectional relationship between CLEC-2 and podoplanin (show PDPN Antibodies) is described and considered in the context of tumour growth and metastasis.

  10. platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 (show GDF2 Antibodies) upon activation by CLEC-2/podoplanin (show PDPN Antibodies) in

Mouse (Murine) C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN (show PDPN Antibodies) on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.

  2. A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis

  3. Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks (show MKKS Antibodies)).

  4. Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36 (show CD36 Antibodies)/GPVI (show GP6 Antibodies) (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2).

  5. Podoplanin (show PDPN Antibodies) and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.

  6. PI3K and Tec (show NR4A3 Antibodies) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Antibodies) phosphorylation downstream of the CLEC-2 receptor

  7. CLEC-2 signaling promotes adhesion to Podoplanin (show PDPN Antibodies) and regulation of Podoplanin (show PDPN Antibodies) signaling, thereby contributing to lymphatic vasculature development.

  8. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN (show PDPN Antibodies) receptor CLEC-2, PDPN (show PDPN Antibodies) endowed FRCs with contractile function and exerted tension within the reticulum.

  9. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2 (show TSG101 Antibodies)(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI (show GP6 Antibodies))-FcRgamma (show FCER1G Antibodies)-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling

  10. The results demonstrated that CLEC-2-dependent platelet activation is insensitive to cGMP-elevation and only partially sensitive to cAMP-elevation.

C-Type Lectin Domain Family 1, Member B (CLEC1B) Antigen Profile

Protein Summary

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000

Gene names and symbols associated with CLEC1B

  • C-type lectin domain family 1, member B (CLEC1B) antibody
  • C-type lectin domain family 1, member B (Clec1b) antibody
  • C-type lectin domain family 1, member B (LOC100346882) antibody
  • C-type lectin domain family 1, member b (Clec1b) antibody
  • 1810061I13Rik antibody
  • Clec-2 antibody
  • CLEC1B antibody
  • Clec2 antibody
  • CLEC2B antibody
  • PRO1384 antibody
  • QDED721 antibody
  • RGD1563517 antibody

Protein level used designations for CLEC1B

C-type lectin domain family 1, member B , C-type lectin domain family 1 member B , c-type lectin domain family 1 member B-like , C-type lectin-like receptor 2 , C-type lectin-like receptor-2 , CLEC-2

GENE ID SPECIES
465283 Pan troglodytes
486696 Canis lupus familiaris
500336 Rattus norvegicus
717404 Macaca mulatta
784092 Bos taurus
100346882 Oryctolagus cuniculus
51266 Homo sapiens
56760 Mus musculus
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