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C-Type Lectin Domain Family 10, Member A Proteins (CLEC10A)

CLEC10A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC10A Antibodies (110) and CLEC10A Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC10A 10462 Q8IUN9
CLEC10A 17312 P49300
CLEC10A 64195  
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Top CLEC10A Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CLEC10A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , ,
Mouse (Murine) , ,
, , ,
Rat (Rattus)

Top referenced CLEC10A Proteins

  1. Human CLEC10A Protein expressed in Human Cells - ABIN2003443 : Dupasquier, Stoitzner, Wan, Cerqueira, van Oudenaren, Voerman, Denda-Nagai, Irimura, Raes, Romani, Leenen: The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling. in Journal of leukocyte biology 2006 (PubMed)
    Show all 2 references for ABIN2003443

  2. Human CLEC10A Protein expressed in HEK-293 Cells - ABIN2180881 : Suzuki, Yamamoto, Toyoshima, Osawa, Irimura: Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)

More Proteins for C-Type Lectin Domain Family 10, Member A (CLEC10A) Interaction Partners

Human C-Type Lectin Domain Family 10, Member A (CLEC10A) interaction partners

  1. BRAF (show BRAF Proteins)(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms.

  2. These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines.

  3. expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL.

  4. MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 (show IL10 Proteins) mRNA levels & enhanced TNF-alpha (show TNF Proteins) mRNA stability. It promoted phosphorylation of the ERK (show EPHB2 Proteins) & CREB (show CREB1 Proteins), fine-tuning the DC maturation phenotype.

  5. Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin (show MBL2 Proteins) family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.

  6. MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8 (show CD8A Proteins)(+) T-cell activation.

Mouse (Murine) C-Type Lectin Domain Family 10, Member A (CLEC10A) interaction partners

  1. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia

  2. Mgl1 (show LLGL1 Proteins)-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility.

  3. MGL1 (show LLGL1 Proteins) is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.

  4. The MGL1 (show LLGL1 Proteins) functions as an attachment and entry receptor for influenza A virus.

  5. Syk (show SYK Proteins) was involved in the CLR (show CALCR Proteins)-mediated activation of mast cells by BP

  6. Hoxc8 (show HOXC8 Proteins) downregulates Mgl1 (show LLGL1 Proteins) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.

  7. The authors conclude that lectin-mediated interactions of influenza virus with the MMR (show MRC1 Proteins) or the MGL are required for the endocytic uptake of the virus into macrophages.

  8. mMGL1 preferentially binds Lewis X (show FUT4 Proteins)-conjugated soluble polyacrylamides

  9. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.

  10. sialoadhesin (show SIGLEC1 Proteins) acts as an endogenous counter-receptor for MGL1 (show LLGL1 Proteins)

CLEC10A Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with CLEC10A

  • C-type lectin domain family 10, member A (CLEC10A)
  • C-type lectin domain family 10, member A (Clec10a)
  • CD301 protein
  • CD301a protein
  • CLEC10A protein
  • CLECSF13 protein
  • CLECSF14 protein
  • HML protein
  • HML2 protein
  • M-ASGP-BP-1 protein
  • Mgl protein
  • Mgl1 protein
  • Mgll protein

Protein level used designations for CLEC10A

C-type lectin domain family 10, member A , C-type lectin, superfamily member 14 , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived) , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived) , C-type lectin domain family 10 member A , macrophage lectin 2 (calcium dependent) , macrophage asialoglycoprotein-binding protein 1 , macrophage galactose N-acetyl-galactosamine specific lectin 1 , Gal/GalNAc-specific lectin , M-ASGP-BP , M-ASGP-BP-1 , MMGL , macrophage galactose/N-acetylgalactosamine-specific lectin , monoglyceride lipase

GENE ID SPECIES
607405 Canis lupus familiaris
748824 Pan troglodytes
10462 Homo sapiens
17312 Mus musculus
64195 Rattus norvegicus
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