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C-Type Lectin Domain Family 12, Member A Proteins (CLEC12A)

CLEC12A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC12A Antibodies (43) and CLEC12A Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC12A 160364 Q5QGZ9
CLEC12A 232413 Q504P2
Rat CLEC12A CLEC12A 680338  
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Top CLEC12A Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$547.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details

CLEC12A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

Top referenced CLEC12A Proteins

  1. Human CLEC12A Protein expressed in Human Cells - ABIN3216398 : Chen, Floyd, Olson, Magaletti, Li, Draves, Clark: Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. in Blood 2006 (PubMed)
    Show all 5 references for ABIN3216398

More Proteins for C-Type Lectin Domain Family 12, Member A (CLEC12A) Interaction Partners

Human C-Type Lectin Domain Family 12, Member A (CLEC12A) interaction partners

  1. We propose the hypothesis that decreased expression of CLEC12A is a common denominator in the hyperinflammatory responses observed in Behcet's syndrome and gout.

  2. Antibacterial autophagy is impaired in CLEC12A-deficient cells, and this effect is exacerbated in the presence of the ATG16L1( *)300A risk allele.

  3. Upon CLL1 (show COLEC10 Proteins)-selective binding of this fusion protein, granulocytes acquire additional TRAIL-mediated cytotoxic activity that, importantly, potentiates antibody-mediated cytotoxicity of clinically used therapeutic antibodies

  4. We conclude the hMICL/CD123 (show IL3RA Proteins)-based MFC assay is a promising MRD tool in AML (show RUNX1 Proteins).

  5. There is a potential genetic association of CLEC12A with rheumatoid arthritis (RA). Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA.

  6. For production of cytotoxic T cells, transgenic DEC-205 (show LY75 Proteins) and Clec9A (show CLEC9A Proteins), but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.

  7. MICL is a negative regulator of granulocyte and monocyte function

  8. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor (show KIR2DL4 Proteins), KLRL1, from human and mouse dendritic cells [KLRL1]

  9. Expression cloning identified the antigen recognized as C-type lectin-like molecule-1, a previously undescribed transmembrane glycoprotein

  10. Dendritic-cell (DC)-associated C-type lectin (show MBL2 Proteins) receptors (CLRs) take up antigens to present to T cells and regulate DC functions.

Mouse (Murine) C-Type Lectin Domain Family 12, Member A (CLEC12A) interaction partners

  1. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.

  2. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.

  3. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor (show KLRD1 Proteins), KLRL1, from human and mouse dendritic cells [KLRL1]

  4. CLL-1 expression is also present on the CD34 (show CD34 Proteins)(+)CD38(-) stem- cell compartment in acute myeloid leukemia (show BCL11A Proteins)

  5. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS (show TLR4 Proteins) as a dendritic cell activation agent

CLEC12A Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.

Gene names and symbols associated with CLEC12A

  • C-type lectin domain family 12, member A (CLEC12A)
  • C-type lectin domain family 12, member a (Clec12a)
  • C-type lectin domain family 12, member A (Clec12a)
  • CLL-1 protein
  • CLL1 protein
  • D230024O04 protein
  • DCAL-2 protein
  • KLRL1 protein
  • MGC179455 protein
  • Micl protein

Protein level used designations for CLEC12A

C-type lectin domain family 12, member A , C-type lectin domain family 12 member A , C-type lectin protein CLL-1 , C-type lectin superfamily , C-type lectin-like molecule-1 , dendritic cell-associated lectin 2 , myeloid inhibitory C-type lectin-like receptor , C-type lectin-like molecule 1

GENE ID SPECIES
477697 Canis lupus familiaris
508740 Bos taurus
100053711 Equus caballus
160364 Homo sapiens
232413 Mus musculus
680338 Rattus norvegicus
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