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CLEC16A encodes a member of the C-type lectin domain containing family. Additionally we are shipping CLEC16A Antibodies (72) and and many more products for this protein.
A possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A.
CLEC16A was found to be a susceptibility factor for SLE, with possible contribution to the development of the disease.
Clec16a knockdown mice showed reduced number of B cells and elevated IgM levels compared with controls.
identify CLEC16A as a pivotal gene in multiple sclerosis that serves as a direct regulator of the human leukocyte antigen class II pathway in antigen-presenting cells.
data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS (show PLA2G15 ELISA Kits) in men.
This study demonstrated that the Polymorphism, Single Nucleotide of CLEC16A is associated with multiple sclerosis in Russia.
The study suggested that a CLEC16A polymorphism may be protective against Vogt-Koyanagi-Harada syndrome syndrome in a Chinese Han population.
Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs.
Forty-eight SNPs, all located in CLEC16A, provided a statistically significant association with type 1 diabetes mellitus, with rs34306440 being most significantly associated. The mechanisim is likely through reduced expression of DEXI transcripts.
Study demonstrates that a diabetogenic SNP in the CLEC16A locus correlates with islet CLEC16A expression, beta cell function, and glycemic control in human subjects. Clec16a controls beta cell function and prevents diabetes by controlling mitophagy.
CLEC16A associations in common variable immunodeficiency disorder represent the first robust evidence of non-HLA associations in this immunodeficiency condition.
The novel Pdx1 (show PDX1 ELISA Kits)-Clec16a-Nrdp1 (show RNF41 ELISA Kits) pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.
Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal beta cell function, Clec16a controls beta cell function and prevents diabetes by controlling mitophagy.
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene.
C-type lectin domain family 16, member A
, KIAA0350 protein-like
, protein CLEC16A-like
, protein CLEC16A