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CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008].. Additionally we are shipping C-Type Lectin Domain Family 2, Member A Antibodies (27) and C-Type Lectin Domain Family 2, Member A Kits (9) and many more products for this protein.
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PDGF (show PDGFA Proteins) upregulates the expression of CLEC-2 (show CLEC1B Proteins) on dendritic cells to induce T regulatory cells.
Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin (show MBL2 Proteins)-like receptor KACL with its high-affinity receptor NKp65 (show KLRF2 Proteins)
CLEC-2 (show CLEC1B Proteins), unlike platelet ITAM receptors, is not regulated by proteolysis and can be used to monitor platelet-derived microparticles
Keratinocytes express KACL and are capable of stimulating NKp65 (show KLRF2 Proteins)-expressing cells in a KACL-dependent manner.
T-cell PILAR signaling through CD161 (show KLRB1 Proteins) supports CD3 (show CD3 Proteins) antibody-dependent and antigen-specific T-cell proliferation by increasing the expression of antiapoptotic Bcl-xL (show BCL2L1 Proteins) and induces secretion of T helper type 1 cytokines
CLEC-2 (show CLEC1B Proteins) is the receptor for podoplanin (show PDPN Proteins), a sialoglycoprotein implicated in tumor-induced platelet aggregation and tumor metastasis[review]
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007
C-type lectin domain family 2 member A
, keratinocyte-associated C-type lectin
, proliferation-induced lymphocyte-associated receptor