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C-Type Lectin Domain Family 4, Member M Proteins (CLEC4M)

CLEC4M encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. Additionally we are shipping C-Type Lectin Domain Family 4, Member M Antibodies (40) and C-Type Lectin Domain Family 4, Member M Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC4M 10332 Q9H2X3
CLEC4M    
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Top C-Type Lectin Domain Family 4, Member M Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details

CLEC4M Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , , ,
Pan troglodytes

Top referenced C-Type Lectin Domain Family 4, Member M Proteins

  1. Human CLEC4M Protein expressed in Human Cells - ABIN2003052 : Feinberg, Mitchell, Drickamer, Weis: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 7 references for ABIN2003052

More Proteins for C-Type Lectin Domain Family 4, Member M (CLEC4M) Interaction Partners

Human C-Type Lectin Domain Family 4, Member M (CLEC4M) interaction partners

  1. CD209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression.

  2. DC-SIGNR expression in peripheral blood mononuclear cells was higher in HIV-1-infected patients, and its positive correlation with viral load and negative with CD4 (show CD4 Proteins)+ T cells counts suggest a potential role of DC-SIGNR in HIV-1 infection.

  3. Study demonstrated that serum levels of DC-SIGNR in lung cancer patients were significantly lower than those in healthy individuals, and correlated significantly with brain metastasis and serum NK cells percentage.

  4. Genetic variations in STXBP5 (show STXBP5 Proteins) and CLEC4M are associated with VWF (show VWF Proteins) level variation in type 1, but not in type 2 von Willebrand disease.

  5. of an association between CD209 (show CD209 Proteins) and CD209L polymorphisms and tuberculosis development in a Brazilian population

  6. DC-SIGN (show CD209 Proteins) and DC-SIGNR are blood-based molecular markers that can potentially be used for the diagnosis of early stage patients

  7. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN (show CD209 Proteins), DC-SIGNR and LSECtin (show CLEC4G Proteins).

  8. The results indicate that neck region polymorphism of L-SIGN can influence the outcome of HCV infection and the four-tandem repeat is associated with clearance of HCV infection.

  9. CLEC4M and CD81 (show CD81 Proteins) both are still crucial for hepatitis C virus entry into hepatocytes.

  10. The CLEC4M carbohydrate recognition domain rapidly and reversibly releases glycan ligands and Ca(2 (show CA2 Proteins)+) at reduced pH.

C-Type Lectin Domain Family 4, Member M (CLEC4M) Protein Profile

Protein Summary

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CLEC4M

  • C-type lectin domain family 4, member M (CLEC4M)
  • CD209B protein
  • CD209L protein
  • CD299 protein
  • DC-SIGN2 protein
  • DC-SIGNR protein
  • DCSIGNR protein
  • HP10347 protein
  • L-SIGN protein
  • LSIGN protein

Protein level used designations for CLEC4M

C-type lectin domain family 4 member M , CD209 antigen-like protein 1 , CD299 antigen , DC-SIGN-related protein , dendritic cell-specific ICAM-3-grabbing non-integrin 2 , liver/lymph node-specific ICAM-3 grabbing non-integrin , liver/lymph node-specific ICAM-3-grabbing non-integrin , mannose binding C-type lectin DC-SIGNR , CD209b antigen

GENE ID SPECIES
10332 Homo sapiens
455661 Pan troglodytes
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