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Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Additionally we are shipping C-Type Lectin Domain Family 6, Member A Proteins (10) and C-Type Lectin Domain Family 6, Member A Kits (9) and many more products for this protein.
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Mouse (Murine) Monoclonal CLEC6A Primary Antibody for FACS, IHC (fro) - ABIN320277
Taylor, Reid, Heinsbroek, Brown, Gordon, Wong: Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. in European journal of immunology 2005
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The results indicate differential roles for Dectin-2 and Mincle (show CLEC4E Antibodies) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.
Dectin-2 may oppose the Th2 response and IL-4 (show IL4 Antibodies)-dependent mucin (show SLC13A2 Antibodies) production in the lungs after infection with C. neoformans, and it may not be required for the production of Th1 (show HAND1 Antibodies), Th17, and proinflammatory cytokines or for clearance of this fungal pathogen.
our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.
Dectin-2 contributes to host immunity against mycobacterial infection through the recognition of Mannose-capped lipoarabinomannan.
Dectin-2 expressed on CD11b (show ITGAM Antibodies)(+) dendritic cells promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation.
beta-mannosyl linkages inhibit CAWS arteritis by negatively regulating dectin-2-dependent signaling in spleen and dendritic cells.
Dectin-2 regulates monocyte-derived dendritic cell function in the pulmonary microenvironment at Dermatophagoides farinae challenge to promote the local inflammatory response.
Solvent-based fractionation revealed that Mincle (show CLEC4E Antibodies) and Dectin-2 recognize lipophilic and hydrophilic components of Malassezia.
Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections.
monocytes and neutrophils depend on dectin-1 (show CLEC7A Antibodies), dectin-2 and complement for the recognition of fungal particles in inflammation
This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.
human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2
The Dectin-2 possess a single extracellular conserved C-type lectin (show MBL2 Antibodies)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.
Thus, dectin-1 (show CLEC7A Antibodies) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1 (show MALT1 Antibodies)-dependent activation of c-Rel (show NFkBP65 Antibodies).
human DECTIN-2 has a role in innate immunity
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
C-type lectin domain family 6, member A
, C-type lectin domain family 6 member A
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10
, C-type lectin superfamily member 10
, DC-associated C-type lectin 2
, dendritic cell-associated C-type lectin 2
, natural killer complex lectin
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
, dectin 2