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C-Type Lectin Domain Family 7, Member A Proteins (CLEC7A)

CLEC7A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC7A Antibodies (179) and CLEC7A Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC7A 56644 Q6QLQ4
CLEC7A 64581 Q9BXN2
Rat CLEC7A CLEC7A 502902  
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Top CLEC7A Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Mouse Fc Tag   50 μg Log in to see 5 to 8 Days
$362.25
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,429.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,429.17
Details

CLEC7A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, ,
Human , , ,
, , ,

Top referenced CLEC7A Proteins

  1. Human CLEC7A Protein expressed in Human Cells - ABIN2002370 : del Pilar Jiménez-A, Viriyakosol, Walls, Datta, Kirkland, Heinsbroek, Brown, Fierer: Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a). in Genes and immunity 2008 (PubMed)
    Show all 2 references for ABIN2002370

  2. Mouse (Murine) CLEC7A Protein expressed in Human Cells - ABIN2007547 : Tsoni, Brown: beta-Glucans and dectin-1. in Annals of the New York Academy of Sciences 2008 (PubMed)
    Show all 2 references for ABIN2007547

More Proteins for C-Type Lectin Domain Family 7, Member A (CLEC7A) Interaction Partners

Pig (Porcine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

  1. These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations

  2. recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 (show ITGAM Proteins) are involved in the beta-glucan-mediated responses in pig macrophages.

Mouse (Murine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

  1. Mast cells are able to phagocytose and produce nitric oxide against Candida albicans via TLR2/Dectin-1.

  2. TREM-1 (show TREM1 Proteins) and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.

  3. Sc CW-derived BG stimulated the late and strong expression of Csf2 (show CSF2 Proteins) in a dectin-1-dependent manner, they remain poor inducers of chemokine (show CCL1 Proteins) and cytokine production in murine macrophages.

  4. recognition of beta-1,3 glucan by Dectin-1 triggers TLR9 (show TLR9 Proteins) trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense.

  5. These observations suggest that Dectin-1 regulates the homeostasis of intestinal immunity by controlling Treg cell differentiation through modification of microbiota.

  6. our findings define the mechanism of receptor crosstalk between CR3 (show ITGAM Proteins) and Dectin-1 and demonstrate the importance of their collaboration in host defense against fungal infection.

  7. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.

  8. Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.

  9. SHH (show SHH Proteins)-responsive 5-lipoxygenase (show ALOX5 Proteins), 15-lipoxygenase and COX-2 modulate Dectin-1-induced inflammatory cytokines.

  10. dectin-1 plays a critical role in the ability of complete Freund's adjuvant to induce experimental autoimmune uveoretinitis in mice.

Human C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

  1. study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (rs5743708) represents an independent risk factor of developing IFD in patients with AML (show RUNX1 Proteins) undergoing induction chemotherapy.

  2. TREM-1 (show TREM1 Proteins) and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.

  3. Our data suggest that the genetic diversity of CLEC7A gene influences the autism spectrum disorders (ASD (show ARSD Proteins)) phenotype by behaving as a disease specifier and imply that the genetic control of innate immune response could determine the ASD (show ARSD Proteins) phenotype.

  4. The result of this study suggests that there is no correlation between Dectin-1 Y238X Gene polymorphism and RVVC.

  5. This study demonstrated that Toll (show TLR4 Proteins)-Like Receptors and Dectin-1, a C-Type Lectin Receptor (show CLEC4D Proteins), Trigger Divergent Functions in CNS Macrophages.

  6. Data indicate that Candida albicans beta-Glucan induces high IL-1 (show IL1A Proteins) receptor antagonist (IL-1Ra (show IL1RN Proteins)) levels, independently from Dectin-1/complement receptor 3 (CR3 (show ITGAM Proteins)).

  7. The analysis of Dectin-1 gene polymorphisms showed no significant association with fungal keratitis in the northern Han Chinese population.

  8. Dectin-1 expressed on human pulmonary epithelial cells has a considerable impact on the Nontypeable Haemophilus influenzae triggered immune response.

  9. The superoxide induction with whole glucan particle was concluded to be Dectin-1-mediated and required Src (show SRC Proteins) family kinases, phosphatidylinositol-3 kinase and protein kinase B/Akt (show AKT1 Proteins).

  10. CARD9 (show CARD9 Proteins) regulates H-Ras (show HRAS Proteins) activation by linking Ras-GRF1 (show RASGRF1 Proteins) to H-Ras (show HRAS Proteins), which mediates Dectin-1-induced extracellular signal-regulated protein kinase (show CDK7 Proteins) (ERK (show EPHB2 Proteins)) activation and proinflammatory responses when stimulated by their ligands.

Cow (Bovine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

  1. CLEC7a genetic variant c.589A>G was significantly associated (p = 0.008) with Mycobacterium avium ssp. paratuberculosis infection in Holsteins cattle.

CLEC7A Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC7A

  • C-type lectin domain family 7, member A (CLEC7A)
  • C-type lectin domain family 7, member a (Clec7a)
  • C-type lectin domain family 7, member A (Clec7a)
  • dendritic cell-associated C-type lectin 1 (LOC100339146)
  • beta-GR protein
  • BGR protein
  • CANDF4 protein
  • CLEC7A protein
  • Clec7b protein
  • CLECSF12 protein
  • DECTIN1 protein
  • RGD1565140 protein

Protein level used designations for CLEC7A

dendritic cell-associated C-type lectin 1 , C-type lectin domain family 7, member A , C-type lectin domain family 7 member A , dectin 1 , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , C-type lectin superfamily member 12 , DC-associated C-type lectin 1 , beta-glucan receptor , dectin-1 , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 , dendritic cell-associated C-type lectin-1 , lectin-like receptor 1

GENE ID SPECIES
473361 Pan troglodytes
611385 Canis lupus familiaris
678685 Ovis aries
100038025 Sus scrofa
56644 Mus musculus
64581 Homo sapiens
532865 Bos taurus
502902 Rattus norvegicus
574356 Macaca mulatta
100339146 Oryctolagus cuniculus
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