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This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Additionally we are shipping FLASH Kits (7) and many more products for this protein.
Showing 10 out of 45 products:
Cow (Bovine) Polyclonal FLASH Primary Antibody for WB - ABIN2784233
Lee, Pi, Lee: Buffer optimization for high resolution of human lung cancer tissue proteins by two-dimensional gel electrophoresis. in Biotechnology letters 2008
Show all 2 references for ABIN2784233
Human Polyclonal FLASH Primary Antibody for EIA, IF - ABIN499842
Imai, Kimura, Murakami, Yajima, Sakamaki, Yonehara: The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. in Nature 1999
Our results indicate that the APAF1 (show APAF1 Antibodies), BAX (show BAX Antibodies), and FLASH genes not only harbor frameshift mutations but also demonstrate mutational ITH, which together might play a role in the tumorigenesis of CRC (show CALR Antibodies) with MSI (show MSI1 Antibodies)-H by affecting the apoptosis of cancer cells.
High-quality solution NMR structures of three homeodomains from human proteins ALX4 (show ALX4 Antibodies), ZHX1 (show ZHX1 Antibodies) and CASP8AP2 were solved.
the predictive values regarding low expressions of H2AFZ (show H2AFZ Antibodies) and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse.
ARS2 (show SRRT Antibodies) and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis.
The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT (show NPAT Antibodies) orthologues, thus acting as a signal targeting proteins to histone locus bodies.
Data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML (show PML Antibodies) bodies.
Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia.
FLASH/Lsm11 (show LSM11 Antibodies) complex bind a unique combination of polyadenylation factors
These data demonstrate that methylation within the Casp8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker and treatment target for drug resistance in cancer cells.
FLASH knockdown in HT1080 (show CDC123 Antibodies) mutant cells defective in p53 (show TP53 Antibodies) did not significantly accelerate Fas (show FAS Antibodies) mediated apoptosis indicating that the effect was dependent on functional p53 (show TP53 Antibodies).
the functional interaction of E2A (show TCF3 Antibodies) and FLASH play an important role in cell proliferation and cellular senescence via regulation of p21 (show D4S234E Antibodies) expression in experimental glomerulonephritis.
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
CASP8 associated protein 2
, caspase 8 associated protein 2
, CASP8-associated protein 2-like
, CASP8-associated protein 2
, FLASH homolog RIP25
, FLICE associated huge
, FLICE-associated huge protein
, human FLASH