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The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. Additionally we are shipping CEBPA Kits (31) and CEBPA Proteins (11) and many more products for this protein.
Showing 10 out of 140 products:
Human Polyclonal CEBPA Primary Antibody for EIA, FACS - ABIN951460
Twu, Hsieh, Lin, Tzeng, Sun, Yu: Phosphorylation status of transcription factor C/EBPalpha determines cell-surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. in Blood 2010
Show all 4 references for ABIN951460
Chicken Polyclonal CEBPA Primary Antibody for IHC, WB - ABIN2787465
Singh, Trivedi, Behre: C/EBPalpha S248A mutation reduces granulocytic differentiation in human leukemic K562 cells. in Biochemical and biophysical research communications 2008
Show all 3 references for ABIN2787465
Human Polyclonal CEBPA Primary Antibody for FACS, WB - ABIN653431
Nanri, Uike, Kawakita, Iwanaga, Mitsuya, Asou: A family harboring a germ-line N-terminal C/EBPalpha mutation and development of acute myeloid leukemia with an additional somatic C-terminal C/EBPalpha mutation. in Genes, chromosomes & cancer 2010
Show all 3 references for ABIN653431
Human Monoclonal CEBPA Primary Antibody for FACS, ELISA - ABIN969507
Geest, Buitenhuis, Vellenga, Coffer: Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. in Haematologica 2009
Human Monoclonal CEBPA Primary Antibody for ICC, FACS - ABIN969048
Jin, Zhang, Yan, Liu, Wang, Ge, Zhai: C/EBPalpha regulates SIRT1 expression during adipogenesis. in Cell research 2010
Cow (Bovine) Polyclonal CEBPA Primary Antibody for WB - ABIN2792649
Zhu, Qian, Levy: CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y. in The Journal of biological chemistry 2004
The efficient repression of E2F (show E2F1 Antibodies) dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBP alpha.
we are the first to identify that miR (show MLXIP Antibodies)-381 suppresses C/EBPalpha-dependent Cx43 (show GJA1 Antibodies) expression in breast cancer cells. The miR (show MLXIP Antibodies)-381-C/EBPalpha-Cx43 (show GJA1 Antibodies) axis might be a useful diagnostic and therapeutic target of metastatic breast cancer
results suggested that C/EBPalpha-saRNA successfully inhibited HCC (show FAM126A Antibodies) metastasis by inhibiting EGFR (show EGFR Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway mediated EMT (show ITK Antibodies) in vitro and in vivo
These results suggest that genetic predisposition to higher IL-6 (show IL6 Antibodies) production is associated with increased risk to HBV infection and hepatic inflammation, which might be due to C/EBPalpha-mediated regulatory effect on Th17 and Treg responses.
the present study demonstrated that suppression of C/EBPa P42 (show EPB42 Antibodies) induced by PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) inhibition impaired the differentiation and ATRA sensitivity of acute promyelocytic leukemia (show PML Antibodies) cells.
Data uncover GCN5 (show KAT2A Antibodies) as a negative regulator of C/EBPalpha and demonstrate the importance of C/EBPalpha acetylation in myeloid differentiation.
younger age, presence of mirror repeats, and high CEBPA expression level in relation to potential topo II-sites, might affect the incidence of B-ZIP in-frame CNVs through aberrant recombination-mediated DNA repair mechanisms.
Reprogramming human B cells into induced pluripotent stem cells and is enhanced by C/EBPa.
this is the first report on the regulation mechanism of SIRT7 (show SIRT7 Antibodies) gene, in which, HDAC3 (show HDAC3 Antibodies) collaborated with C/EBPalpha to occupy its responding element in the upstream region of SIRT7 (show SIRT7 Antibodies) gene and repressed its expression in human cells.
Results show that CEBPA in combinations with FLT3 (show FLT3 Antibodies) and NPM1 (show NPM1 Antibodies) genotype confer favourable prognosis in AML (show RUNX1 Antibodies)
Cebpa enhancers and silencers in a transcriptional model have roles in hematopoietic lineage specification
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Antibodies)) expression and increasing the levels of histone demethylase (show MBD2 Antibodies) Lsd1 (show KDM1A Antibodies) and transcription factor Brd4 (show BRD4 Antibodies) in B cell.
The findings demonstrate a critical role for the +37 kb Cebpa enhancer for hematopoietic-specific Cebpa expression, with enhancer deletion leading to impaired myelopoiesis and potentially preleukemic progenitor expansion.
Data indicate that miR (show MLXIP Antibodies)-25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3-L1 adipogenesis by targeting KLF4 (show KLF4 Antibodies) and C/EBPalpha, which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation.
MYB (show MYB Antibodies) and C/EBPalpha activities are inter-dependent in controlling Flt3 (show FLT3 Antibodies) expression to influence lineage commitment of multipotential progenitors.
Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a (show FCER1A Antibodies)(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Antibodies)).
miR (show MLXIP Antibodies)-223 regulates adipocyte and osteoblast differentiation through a novel C/EBPs/miR (show MLXIP Antibodies)-223/FGFR2 (show FGFR2 Antibodies) regulatory feedback loop.
Data (including data from studies in transgenic/mutant mice) suggest Cebpa (CCAAT-enhancer binding protein alpha) in myeloid cells is down-regulated in type 2 diabetes resulting in poor maturation of Gr-1 (show GSR Antibodies)+ (chemokine receptor (show CCR1 Antibodies)) myeloid cells.
C/EBPalpha is required for the increased lipogenesis. C/EBPalpha plays a role in mediating the lipogenic effects of hepatic Trib1 (show TRIB1 Antibodies) deletion.
C/ebpalpha plays a role in liver growth regulation via the p53 (show TP53 Antibodies) pathway.
Dnmt1 (show DNMT1 Antibodies) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (show ALDH1L1 Antibodies)) involving CEBPalpha helps relieve embryonic oxidative stress induced (show SQSTM1 Antibodies) by ethanol exposure.
Bmi1 (show BMI1 Antibodies) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (show SUMO1 Antibodies), SUMO2 (show SUMO2 Antibodies), and SUMO3 (show SUMO3 Antibodies)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN (show PTEN Antibodies)-C/EBPalpha-CTNNA1 (show CTNNA1 Antibodies) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (show IL6 Antibodies)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (show MSTN Antibodies) in muscles were higher in the concentrate-fed group than in the grass hay (show GTF2H5 Antibodies)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha