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The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. Additionally we are shipping CEBPA Antibodies (138) and CEBPA Kits (31) and many more products for this protein.
Showing 9 out of 11 products:
Human CEBPA Protein expressed in Escherichia coli (E. coli) - ABIN666625
Gombart, Hofmann, Kawano, Takeuchi, Krug, Kwok, Larsen, Asou, Miller, Hoelzer, Koeffler: Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. in Blood 2002
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The p53 (show TP53 Proteins)-KLF4 (show KLF4 Proteins)-CEBPA axis is deregulated in AML (show RUNX1 Proteins) but can be functionally restored by conventional chemotherapy and novel p53 (show TP53 Proteins) activating treatments.
C/EBPalpha inhibited breast cancer cell growth via a novel miR (show MLXIP Proteins)-134/CREB (show CREB1 Proteins) signaling pathway.
C/EBP-alpha was primarily expressed in hepatocytes in normal liver, but its expression decreased significantly in liver fibrosis
The efficient repression of E2F (show E2F1 Proteins) dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBP alpha.
we are the first to identify that miR (show MLXIP Proteins)-381 suppresses C/EBPalpha-dependent Cx43 (show GJA1 Proteins) expression in breast cancer cells. The miR (show MLXIP Proteins)-381-C/EBPalpha-Cx43 (show GJA1 Proteins) axis might be a useful diagnostic and therapeutic target of metastatic breast cancer
results suggested that C/EBPalpha-saRNA successfully inhibited HCC (show FAM126A Proteins) metastasis by inhibiting EGFR (show EGFR Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway mediated EMT (show ITK Proteins) in vitro and in vivo
These results suggest that genetic predisposition to higher IL-6 (show IL6 Proteins) production is associated with increased risk to HBV infection and hepatic inflammation, which might be due to C/EBPalpha-mediated regulatory effect on Th17 and Treg responses.
the present study demonstrated that suppression of C/EBPa P42 (show EPB42 Proteins) induced by PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) inhibition impaired the differentiation and ATRA sensitivity of acute promyelocytic leukemia (show PML Proteins) cells.
Data uncover GCN5 (show KAT2A Proteins) as a negative regulator of C/EBPalpha and demonstrate the importance of C/EBPalpha acetylation in myeloid differentiation.
younger age, presence of mirror repeats, and high CEBPA expression level in relation to potential topo II-sites, might affect the incidence of B-ZIP in-frame CNVs through aberrant recombination-mediated DNA repair mechanisms.
Cebpa enhancers and silencers in a transcriptional model have roles in hematopoietic lineage specification
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase Lsd1 (show KDM1A Proteins) and transcription factor Brd4 (show BRD4 Proteins) in B cell.
The findings demonstrate a critical role for the +37 kb Cebpa enhancer for hematopoietic-specific Cebpa expression, with enhancer deletion leading to impaired myelopoiesis and potentially preleukemic progenitor expansion.
Data indicate that miR (show MLXIP Proteins)-25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3-L1 adipogenesis by targeting KLF4 (show KLF4 Proteins) and C/EBPalpha, which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation.
MYB (show MYB Proteins) and C/EBPalpha activities are inter-dependent in controlling Flt3 (show FLT3 Proteins) expression to influence lineage commitment of multipotential progenitors.
Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a (show FCER1A Proteins)(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)).
miR (show MLXIP Proteins)-223 regulates adipocyte and osteoblast differentiation through a novel C/EBPs/miR (show MLXIP Proteins)-223/FGFR2 (show FGFR2 Proteins) regulatory feedback loop.
Data (including data from studies in transgenic/mutant mice) suggest Cebpa (CCAAT-enhancer binding protein alpha) in myeloid cells is down-regulated in type 2 diabetes resulting in poor maturation of Gr-1 (show GSR Proteins)+ (chemokine receptor (show CCR1 Proteins)) myeloid cells.
C/EBPalpha is required for the increased lipogenesis. C/EBPalpha plays a role in mediating the lipogenic effects of hepatic Trib1 (show TRIB1 Proteins) deletion.
C/ebpalpha plays a role in liver growth regulation via the p53 (show TP53 Proteins) pathway.
Dnmt1 (show DNMT1 Proteins) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (show ALDH1L1 Proteins)) involving CEBPalpha helps relieve embryonic oxidative stress induced (show SQSTM1 Proteins) by ethanol exposure.
Bmi1 (show BMI1 Proteins) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (show SUMO1 Proteins), SUMO2 (show SUMO2 Proteins), and SUMO3 (show SUMO3 Proteins)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (show CTNNA1 Proteins) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (show IL6 Proteins)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (show MSTN Proteins) in muscles were higher in the concentrate-fed group than in the grass hay (show GTF2H5 Proteins)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha