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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (74) and CTCF Proteins (7) and many more products for this protein.
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We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 ELISA Kits) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis.
TGF-beta (show TGFB1 ELISA Kits)/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Results indicate that CTCF binding polarity plays a functional role in the formation of higher-order chromatin structure.
Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus
CTCF controls the homeostatic maintenance and migration of Langerhans cells.
MyoD (show MYOD1 ELISA Kits) affects chromatin looping at CCCTC-binding factor-binding sites represents the first evidence that a differentiation factor regulates chromatin-loop dynamics
Findings establish CTCF as a prominent tumor-suppressor gene and point to CTCF-mediated epigenetic stability as a major barrier to neoplastic progression.
CTCF is recruited in a locus-specific manner and CTCF-RNA interactions may be involved in long-range chromosomal interactions.
TET1/DNA methylation (show HELLS ELISA Kits)-dependent nucleosome repositioning is the main mechanism that drives differential CTCF binding site selection during stem cell development.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
CTCF is involved in regulating endocrine function of pancreatic islet cells by suppression of Pax6 (show PAX6 ELISA Kits) expression.
The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes.
CSB and CTCF can regulate each other's chromatin association, thereby modulating chromatin structure and coordinating gene expression in response to oxidative stress.
CTCF binds to the provirus at a sharp border in epigenetic modifications in the pX region of the HTLV-1 provirus in T cells naturally infected with HTLV-1. This may cause widespread abnormalities in host cell chromatin structure and gene expression.
CTCF/cohesin coordinates HOXA cluster higher-order chromatin structure and expression during development
CTCF has a role in regulating SLC45A3-ELK4 (show ELK4 ELISA Kits) Chimeric RNA
CTCF helps recruit CENP-E (show CENPE ELISA Kits) to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF/CENP-E (show CENPE ELISA Kits) complex.
Here, the authors reveal the methylcytosine dioxygenases TET1 and TET2 (show TET2 ELISA Kits) as active regulators of CTCF-mediated alternative splicing through conversion of 5-methylcytosine to its oxidation derivatives.
These results demonstrate the existence of definitive CTCF binding motifs corresponding to CTCF's diverse functions.
the CTCF-associated boundary element, CBS5, employs both Cohesin and noncoding RNA to establish and maintain topologically associated domains at the HOXA locus.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor