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CCCTC-Binding Factor (Zinc Finger Protein) Proteins (CTCF)

CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (73) and CTCF Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTCF 13018 Q61164
CTCF 10664 P49711
CTCF 83726 Q9R1D1
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Top CTCF Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,154.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$522.50
Details

CTCF Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced CTCF Proteins

  1. Human CTCF Protein expressed in Wheat germ - ABIN1350629 : Shukla, Kavak, Gregory, Imashimizu, Shutinoski, Kashlev, Oberdoerffer, Sandberg, Oberdoerffer: CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. in Nature 2011 (PubMed)
    Show all 3 references for ABIN1350629

More Proteins for CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) Interaction Partners

Zebrafish CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) interaction partners

  1. We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 Proteins) during zebrafish embryogenesis.

  2. Data conclude that CTCF modulates MRF (show C11orf9 Proteins) functional interactions in the orchestration of myogenesis.

Mouse (Murine) CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) interaction partners

  1. TGF-beta (show TGFB1 Proteins)/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

  2. Results indicate that CTCF binding polarity plays a functional role in the formation of higher-order chromatin structure.

  3. Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus

  4. CTCF controls the homeostatic maintenance and migration of Langerhans cells.

  5. MyoD (show MYOD1 Proteins) affects chromatin looping at CCCTC-binding factor-binding sites represents the first evidence that a differentiation factor regulates chromatin-loop dynamics

  6. Findings establish CTCF as a prominent tumor-suppressor gene and point to CTCF-mediated epigenetic stability as a major barrier to neoplastic progression.

  7. CTCF is recruited in a locus-specific manner and CTCF-RNA interactions may be involved in long-range chromosomal interactions.

  8. TET1 (show TET1 Proteins)/DNA methylation (show HELLS Proteins)-dependent nucleosome repositioning is the main mechanism that drives differential CTCF binding site selection during stem cell development.

  9. NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin

  10. CTCF is involved in regulating endocrine function of pancreatic islet cells by suppression of Pax6 (show PAX6 Proteins) expression.

Human CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) interaction partners

  1. Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression.

  2. Mutational analysis highlighted a potential role for CTCF, a crucial regulator of long-range chromatin interactions, in head and neck cancer progression.

  3. CTCF and cohesins shape the genome during evolution. (Review)

  4. The action of SNF2H (show SMARCA5 Proteins) at CTCF sites is functionally important as depletion of CTCF or SNF2H (show SMARCA5 Proteins) affects transcription of a common group of genes.

  5. CSB (show ERCC6 Proteins) and CTCF can regulate each other's chromatin association, thereby modulating chromatin structure and coordinating gene expression in response to oxidative stress.

  6. CTCF binds to the provirus at a sharp border in epigenetic modifications in the pX region of the HTLV-1 provirus in T cells naturally infected with HTLV-1. This may cause widespread abnormalities in host cell chromatin structure and gene expression.

  7. CTCF/cohesin coordinates HOXA cluster higher-order chromatin structure and expression during development

  8. CTCF has a role in regulating SLC45A3-ELK4 (show ELK4 Proteins) Chimeric RNA

  9. TGF-beta (show TGFB1 Proteins)/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

  10. CTCF helps recruit CENP-E (show CENPE Proteins) to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF/CENP-E (show CENPE Proteins) complex.

CTCF Protein Profile

Protein Summary

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CTCF

  • CCCTC-binding factor (zinc finger protein) (CTCF)
  • CCCTC-binding factor (zinc finger protein) (ctcf)
  • CCCTC-binding factor (zinc finger protein) (LOC100224119)
  • CCCTC-binding factor (Ctcf)
  • CCCTC-binding factor (zinc finger protein) (Ctcf)
  • AW108038 protein
  • CTCF protein
  • im:7152666 protein
  • xctcf protein

Protein level used designations for CTCF

transcriptional repressor CTCF , CCCTC-binding factor (zinc finger protein) , transcriptional repressor CTCF-like , 11-zinc finger protein , CTCFL paralog , 11 zinc finger transcriptional repressor

GENE ID SPECIES
100053363 Equus caballus
415104 Danio rerio
454169 Pan troglodytes
100101689 Xenopus (Silurana) tropicalis
100224119 Taeniopygia guttata
100350641 Oryctolagus cuniculus
100465401 Ailuropoda melanoleuca
13018 Mus musculus
10664 Homo sapiens
396274 Gallus gallus
479684 Canis lupus familiaris
517097 Bos taurus
83726 Rattus norvegicus
100623274 Sus scrofa
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