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CCCTC-Binding Factor (Zinc Finger Protein)-Like Proteins (CTCFL)

CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. Additionally we are shipping CTCFL Antibodies (70) and CTCFL Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CTCFL CTCFL 296420  
CTCFL 140690 Q8NI51
CTCFL 664799 A2APF3
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Top CTCFL Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CTCFL Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) Interaction Partners

Human CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

  1. BORIS is associated with cancer stem cell-enriched populations of several epithelial tumor cells and the different phenotypes depend on the origin of tumor cells.

  2. Data found that BORIS and CTCF (show CTCF Proteins) expression in low-grade squamous intraepithelial lesions and invasive cervical carcinoma is higher than in normal samples. The possible utility of BORIS and CTCF (show CTCF Proteins) as biomarkers in cervical neoplasm requires further analysis.

  3. In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS/CTCF (show CTCF Proteins) ratio indicate frequent disruption of CTCF (show CTCF Proteins) and its effector genes in PCa (show FLVCR1 Proteins).

  4. Differential regulation of MAGE (show MAGEB10 Proteins)-A1 promoter activity by BORIS and Sp1 (show PSG1 Proteins), both interacting with the TATA binding protein (show TBP Proteins).

  5. High BORIS transcript variants are associated with laryngeal squamous cell carcinomas.

  6. CTCFL/BORIS was amongst the top ranked genes differentially expressed between endometrioid and non-endometrioid tumors, and increasing mRNA level of CTCFL/BORIS was highly significantly associated with poor survival.

  7. The serum levels of MAGE (show MAGEB10 Proteins)-A and BORIS mRNA, as well as let-7b were significantly higher in patients.

  8. results provide novel insights into the determinants of NOTCH3 (show NOTCH3 Proteins) overexpression in cancer cells, by revealing a key role for BORIS as the main mediator of transcriptional deregulation of NOTCH3 (show NOTCH3 Proteins)

  9. BORIS is an RNA-binding protein that associates with polysomes.

  10. Neither the MTHFR (show MTHFR Proteins) polymorphism, nor CTCFL mutations explain a pattern of sperm hypomethylation at paternally imprinting loci

Mouse (Murine) CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

  1. The TGFB (show TGFB1 Proteins) pathway as most affected by embryonic Ctcfl expression.

  2. down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.

  3. Rb2 (show RBL2 Proteins) coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF (show CTCF Proteins)) and BORIS in T-antigen-positive but not in T-antigen-negative cells.

  4. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function.

  5. findings indicate that BORIS-induced expression of TSP50 (show PRSS50 Proteins) is governed by accessibility and binding of BORIS to the promoter

  6. These findings define transcriptional regulation of CST (Gal3st1 (show GAL3ST1 Proteins)) expression as a critical role for BORIS in spermatogenesis.

  7. CTCFL and PRMT7 (show PRMT7 Proteins) may play a role in male germline imprinted gene methylation.

  8. CTCFL/BORIS is a methylation-independent DNA-binding protein (show HSF4 Proteins) that preferentially binds to the paternal H19 (show NCKAP1 Proteins) differentially methylated region

  9. DNA damage-induced and ATR/Rfx1 (show RFX1 Proteins)-mediated increase of miR (show MLXIP Proteins)-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation (show HELLS Proteins) after radiation exposure.

CTCFL Protein Profile

Protein Summary

CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CTCFL

  • CCCTC-binding factor (zinc finger protein)-like (Ctcfl)
  • CCCTC-binding factor (zinc finger protein)-like (CTCFL)
  • CCCTC-binding factor (zinc finger protein)-like (LOC100360757)
  • Boris protein
  • CT27 protein
  • CTCF-T protein
  • CTCFL protein
  • dJ579F20.2 protein
  • HMGB1L1 protein
  • OTTMUSG00000016680 protein

Protein level used designations for CTCFL

CCCTC-binding factor (zinc finger protein)-like , CCCTC-binding factor-like protein , brother of the regulator of imprinted sites , brother of regulator of imprinted sites , transcriptional repressor CTCFL , transcriptional repressor CTCFL-like , BORIS-like protein , CTCF paralog , CTCF-like protein , HMG-1L1 , cancer/testis antigen 27 , putative high mobility group protein 1-like 1 , putative high mobility group protein B1-like 1 , zinc finger protein CTCF-T , BORIS , Brother of the regulator of imprinted sites , likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL)

GENE ID SPECIES
296420 Rattus norvegicus
458360 Pan troglodytes
477271 Canis lupus familiaris
100079649 Ornithorhynchus anatinus
100144618 Bos taurus
100360757 Rattus norvegicus
100475700 Ailuropoda melanoleuca
701500 Macaca mulatta
100126237 Sus scrofa
100140647 Bos taurus
100435120 Pongo abelii
100583303 Nomascus leucogenys
100618914 Monodelphis domestica
140690 Homo sapiens
664799 Mus musculus
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