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The protein encoded by CNOT6 is a subunit of the CCR4-NOT core transcriptional regulation complex. Additionally we are shipping CNOT6 Antibodies (33) and CNOT6 Kits (9) and many more products for this protein.
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miR (show MLXIP Proteins)-29c-3p promotes the senescence of Mesenchymal stem cells by targeting CNOT6 through p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins) and p16-pRB (show RB1 Proteins) pathways.
These results indicate that Caf1 (show CHAF1B Proteins) and Ccr4 (show CCR4 Proteins) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (show CHAF1B Proteins) and Ccr4 (show CCR4 Proteins) are regulated via allosteric interactions within the nuclease (show DCLRE1C Proteins) module.
Results identified CNOT6/CNOT6L (show CNOT6L Proteins) as a key regulator of insulin-like growth factor-binding protein 5 (show IGFBP5 Proteins), which mediates cell cycle arrest and senescence via a p53 (show TP53 Proteins)-dependent pathway.
CCR4 (show CCR4 Proteins) and BTG2 (show BTG2 Proteins) interact and have a role in cell-cycle regulation
CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1
hCCR4/cNOT6 targets DNA-damage response proteins
Data show that Ccr4 (show CCR4 Proteins)-Not function in RNA splicing and nuclear export, and that CNOT6 binds CNOT8 (show CNOT8 Proteins) in yeast two-hybrid assays.
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates.
CCR4-NOT transcription complex subunit 6
, CCR4-NOT transcription complex, subunit 6
, Cytoplasmic deadenylase
, carbon catabolite repression 4 protein
, carbon catabolite repressor protein 4 homolog
, cytoplasmic deadenylase