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Plays a role in the deadenylation of mRNAs in the cytoplasm. Additionally we are shipping CNOT6L Kits (9) and CNOT6L Proteins (3) and many more products for this protein.
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Data show that CNOT6L protein-interleukin 8 (IL-8 (show IL8 Antibodies)) is a signaling axis in myogenesis.
Cnot6L, a validated target of miR (show MLXIP Antibodies)-146a, affects the stability of Zeb1 (show ZEB1 Antibodies) mRNA.
Results identified CNOT6 (show CNOT6 Antibodies)/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5 (show IGFBP5 Antibodies), which mediates cell cycle arrest and senescence via a p53 (show TP53 Antibodies)-dependent pathway.
show that the nuclease (show DCLRE1C Antibodies) domain of CNOT6L exhibits full Mg(2 (show MUC7 Antibodies)+)-dependent deadenylase activity with strict poly(A) RNA substrate specificity.
CCR4b may be involved in various cellular events that include cell proliferation.
Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA (By similarity).
CCR4-NOT transcription complex subunit 6-like
, carbon catabolite repressor protein 4 homolog B