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anti-CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) Antibodies

Ubiquitous transcription factor required for a diverse set of processes. Additionally we are shipping CNOT8 Kits (7) and CNOT8 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CNOT8 363603  
CNOT8 9337 Q9UFF9
CNOT8 69125 Q9D8X5
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Top anti-CNOT8 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of CNOT8 (arrow) using rabbit polyclonal CNOT8 Antibody (N-term) (ABIN656816). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CNOT8 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB CAF-1 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CAF-1 antibody detected the CAF-1 protein (arrow). CAF-1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CAF-1 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CNOT8 (arrow) using rabbit polyclonal CNOT8 Antibody (N-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CNOT8 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of CNOT8 Antibody (C-term) (ABIN390421) in CEM cell line lysates (35 µg/lane). CNOT8 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human colon carcinoma with CNOT8 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image CNOT8 antibody detects CNOT8 protein at nucleus and cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CNOT8 protein stained by CNOT8 antibody , diluted at 1:200. Blue: Hoechst 33342 staining. WB Image Sample (30 ug of whole cell lysate) A: SK-N-SH 12% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IF, IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

CNOT8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CNOT8 Antibodies

  1. Human Polyclonal CNOT8 Primary Antibody for WB - ABIN656816 : Ruan, Osawa, Hosoda, Imai, Machiyama, Katada, Hoshino, Shimada: Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN656816

  2. Human Polyclonal CNOT8 Primary Antibody for EIA, WB - ABIN951588 : Marchese, Aubareda, Tudor, Saklatvala, Clark, Dean: MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN951588

  3. Human Polyclonal CNOT8 Primary Antibody for IF, IHC (p) - ABIN655064 : Aslam, Mittal, Koch, Andrau, Winkler: The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. in Molecular biology of the cell 2009 (PubMed)
    Show all 4 references for ABIN655064

  4. Human Polyclonal CNOT8 Primary Antibody for EIA, WB - ABIN452854 : Morel, Sentis, Bianchin, Le Romancer, Jonard, Rostan, Rimokh, Corbo: BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. in Journal of cell science 2003 (PubMed)
    Show all 2 references for ABIN452854

More Antibodies against CNOT8 Interaction Partners

Zebrafish CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) interaction partners

  1. Pharmacological inhibition of FGF signaling or a mutation in the fgf3 (show FGF3 Antibodies) gene can compensate the gain of caudal (show CAD Antibodies) hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 (show FGF3 Antibodies) in control of development of this dopaminergic population

Human CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) interaction partners

  1. These results indicate that Caf1 (show CHAF1B Antibodies) and Ccr4 (show CCR4 Antibodies) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (show CHAF1B Antibodies) and Ccr4 (show CCR4 Antibodies) are regulated via allosteric interactions within the nuclease (show DCLRE1C Antibodies) module.

  2. CNOT7 (show CNOT7 Antibodies)/hCAF1 is involved in ICAM-1 (show ICAM1 Antibodies) and IL-8 (show IL8 Antibodies) regulation by TTP (show ADAMTS13 Antibodies) in HPMEC.

  3. show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4 (show CCR4 Antibodies)-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets

  4. The anti-proliferative activity of BTG/TOB (show TDO2 Antibodies) proteins is mediated via the Caf1a (show CHAF1B Antibodies) (CNOT7 (show CNOT7 Antibodies)) and Caf1b (show CHAF1A Antibodies) (CNOT8) deadenylase subunits of the Ccr4 (show CCR4 Antibodies)-not complex.

  5. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.

  6. N-terminus played a role in modulating hCaf1 activity, stability and aggregation

  7. Together, these results indicate that Tob (show TDO2 Antibodies) mediates the recruitment of Caf1 (show CHAF1B Antibodies) to the target of CPEB3 (show CPEB3 Antibodies) and elicits deadenylation and decay of the mRNA.

  8. MK2 (show KCNA2 Antibodies) phosphorylation reduces the ability of TTP (show ADAMTS13 Antibodies) to promote deadenylation by inhibiting the recruitment of CAF1 (show CHAF1B Antibodies) deadenylase in a mechanism that does not involve sequestration of TTP (show ADAMTS13 Antibodies) by 14-3-3 (show YWHAQ Antibodies).

  9. Tob (show TDO2 Antibodies) interactions with Caf1 (show CHAF1B Antibodies) and a C-terminal domain of PABPC1 (show PABPC1 Antibodies)

  10. CCR4 (show CCR4 Antibodies)-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells.

CNOT8 Antigen Profile

Protein Summary

Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex (By similarity).

Gene names and symbols associated with CNOT8

  • CCR4-NOT transcription complex, subunit 8 (Cnot8) antibody
  • CCR4-NOT transcription complex, subunit 8 (CNOT8) antibody
  • CCR4-NOT transcription complex, subunit 8 (cnot8) antibody
  • CCR4-NOT transcription complex subunit 8 (PAAG_04884) antibody
  • CCR4-NOT transcription complex subunit 8 (VDBG_08730) antibody
  • 1500015I04Rik antibody
  • 1810022F04Rik antibody
  • AA536816 antibody
  • AU015770 antibody
  • AU043059 antibody
  • CAF1 antibody
  • Caf1b antibody
  • CALIF antibody
  • hCAF1 antibody
  • POP2 antibody
  • wu:fe49a05 antibody
  • zgc:63844 antibody

Protein level used designations for CNOT8

CCR4-NOT transcription complex subunit 8 , CCR4-NOT transcription complex, subunit 8 , ccr4-not transcription complex subunit 8 , CAF1-like protein , CAF2 , CALIFp , CCR4-associated factor 8 , PGK promoter directed over production

GENE ID SPECIES
363603 Rattus norvegicus
416255 Gallus gallus
379811 Xenopus laevis
406788 Danio rerio
549332 Xenopus (Silurana) tropicalis
100528541 Ictalurus punctatus
533443 Bos taurus
9096558 Paracoccidioides sp. 'lutzii' Pb01
9534322 Verticillium alfalfae VaMs.102
9337 Homo sapiens
69125 Mus musculus
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