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Ubiquitous transcription factor required for a diverse set of processes. Additionally we are shipping CNOT8 Antibodies (89) and CNOT8 Proteins (5) and many more products for this protein.
Pharmacological inhibition of FGF signaling or a mutation in the fgf3 (show FGF3 ELISA Kits) gene can compensate the gain of caudal (show CAD ELISA Kits) hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 (show FGF3 ELISA Kits) in control of development of this dopaminergic population
These results indicate that Caf1 (show CHAF1B ELISA Kits) and Ccr4 (show CCR4 ELISA Kits) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (show CHAF1B ELISA Kits) and Ccr4 (show CCR4 ELISA Kits) are regulated via allosteric interactions within the nuclease (show DCLRE1C ELISA Kits) module.
CNOT7 (show CNOT7 ELISA Kits)/hCAF1 is involved in ICAM-1 (show ICAM1 ELISA Kits) and IL-8 (show IL8 ELISA Kits) regulation by TTP (show ADAMTS13 ELISA Kits) in HPMEC.
show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4 (show CCR4 ELISA Kits)-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets
The anti-proliferative activity of BTG/TOB (show TDO2 ELISA Kits) proteins is mediated via the Caf1a (show CHAF1B ELISA Kits) (CNOT7 (show CNOT7 ELISA Kits)) and Caf1b (show CHAF1A ELISA Kits) (CNOT8) deadenylase subunits of the Ccr4 (show CCR4 ELISA Kits)-not complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
N-terminus played a role in modulating hCaf1 activity, stability and aggregation
Together, these results indicate that Tob (show TDO2 ELISA Kits) mediates the recruitment of Caf1 (show CHAF1B ELISA Kits) to the target of CPEB3 (show CPEB3 ELISA Kits) and elicits deadenylation and decay of the mRNA.
MK2 (show KCNA2 ELISA Kits) phosphorylation reduces the ability of TTP (show ADAMTS13 ELISA Kits) to promote deadenylation by inhibiting the recruitment of CAF1 (show CHAF1B ELISA Kits) deadenylase in a mechanism that does not involve sequestration of TTP (show ADAMTS13 ELISA Kits) by 14-3-3 (show YWHAQ ELISA Kits).
Tob (show TDO2 ELISA Kits) interactions with Caf1 (show CHAF1B ELISA Kits) and a C-terminal domain of PABPC1 (show PABPC1 ELISA Kits)
CCR4 (show CCR4 ELISA Kits)-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells.
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex (By similarity).
CCR4-NOT transcription complex subunit 8
, CCR4-NOT transcription complex, subunit 8
, ccr4-not transcription complex subunit 8
, CAF1-like protein
, CCR4-associated factor 8
, PGK promoter directed over production